Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs

Journal of Atherosclerosis and Thrombosis
Sohsuke YamadaAkihide Tanimoto

Abstract

We have recently established a novel swine model for studies of atherosclerosis using MicrominipigsTM (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries. The µMPs were fed HcD supplemented with 0.7% CA (HcD+CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adiposity and lesion formation in the aorta, liver, and other organs was investigated. The HcD+CA-fed group exhibited more visceral adiposity, progression of atherosclerosis and higher serum levels of oxidative stress markers than the HcD-fed group, even though they showed similar serum lipid levels. The liver demonstrated increased lipid accumulation, higher expression of oxidative stress markers, accelerated activation of foamy Kupffer cells and stellate cells, and increased hepatocyte apoptosis, indicating non-alcoholic fatty liver disease (NAFLD). Intriguingly, foamy macrophage mobilization was observed in various organs, including the reticuloendothelial system, pulmonary capillary vessels and skin very often in HcD+CA-fed µMPs. To our knowledge, this is the first large an...Continue Reading

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Citations

Aug 29, 2018·International Journal of Molecular Sciences·Jing ZhangSohsuke Yamada
Apr 5, 2019·Journal of Translational Medicine·Camilla Schumacher-PetersenLisbeth Høier Olsen
Oct 6, 2020·Journal of Atherosclerosis and Thrombosis·Daiki YoshiiAkihide Tanimoto

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Methods Mentioned

BETA
electrophoresis
ELISA
Assay
MDA

Software Mentioned

NIH image
NIS
Elements D

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