Cholic acid micelles--controlling the size of the aqueous cavity by PEGylation

Physical Chemistry Chemical Physics : PCCP
F DespaK S Lam

Abstract

Data show that cholic acid (CA) micelles are less densely packed and much smaller than micelles formed by typical surfactants, suggesting that CA derivatives can be used to synthesize drug nanocarriers. Presumably, the formation of internal cavities is favored by the facial characteristics of the CA molecule, i.e. the convex molecular structure that is hydrophobic on one side and hydrophilic on the other. Here, we present a thermodynamical approach to quantify the effect of facial characteristics on forces governing the self-assembling process of CA molecules. We show that facial characteristics favor the entrapment of water molecules at interfaces upon CA aggregation, which weakens the attraction between CA hydrophobic moieties. Our computer simulations suggest that these effects contribute significantly to the tendency of CA molecules to form small "hollow-core" micelles. The attachment of polyethylene glycol (PEG) molecular chains to CA increases the repulsive forces in the system, reducing even further the micelle size. We use the present molecular model and experimental critical micelle concentration (cmc) data for CA-PEG systems to predict the change of the micelle size and cavity volume with the increase of the PEG chain...Continue Reading

References

Mar 18, 1994·Science·R GrefR Langer
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·A PertsemlidisR M Glaeser
Oct 23, 1997·Biophysical Journal·T Head-GordonR M Glaeser
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·A PertsemlidisT Head-Gordon
Dec 22, 1999·The EMBO Journal·B van den BergC M Dobson
Apr 30, 2004·Journal of Computational Chemistry·Junmei WangDavid A Case
Mar 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·G J Kleywegt, T A Jones
Sep 24, 2004·Journal of the American Chemical Society·Elizabeth R GilliesJean M J Fréchet
Dec 17, 2004·Physical Review Letters·Florin DespaR Stephen Berry
Oct 4, 2005·Journal of Computational Chemistry·David A CaseRobert J Woods
Sep 26, 2006·Biophysical Journal·Florin Despa, R Stephen Berry
Apr 12, 2007·Expert Review of Neurotherapeutics·K K Jain
Feb 22, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Nicholas W Suek, Monica H Lamm
Aug 5, 2008·Biophysical Journal·F Despa, R S Berry

❮ Previous
Next ❯

Citations

Apr 28, 2012·Journal of Materials Science. Materials in Medicine·Xiu-Hua WangZhi Yuan
May 31, 2011·The Journal of Physical Chemistry. B·Hwankyu Lee, Richard W Pastor
Jun 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefano SalmasoPaolo Caliceti
Nov 22, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Qin TianZhi Yuan
Apr 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Van Tran Thi ThuyDukjoon Kim
Feb 14, 2021·International Journal of Molecular Sciences·Maria Chiara di GregorioLuciano Galantini
Dec 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Shou-Chuang Yang, Roland Faller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yuanpei LiKit S Lam
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Stefano SalmasoPaolo Caliceti
Advanced Drug Delivery Reviews
Deirdre Murphy Piedmonte, Michael J Treuheit
© 2021 Meta ULC. All rights reserved