PMID: 696339Aug 1, 1978Paper

Choline acetyltransferase activity in postganglionic parasympathetic nerves after "pharmacological decentralization"

Acta Pharmacologica Et Toxicologica
J Ekström, B Lindmark

Abstract

The ganglion blocking drug chlorisondamine given frequently and in gradually increasing doses over a period of time to adult rats causes the activity of choline acetyltransferase to fall in the postganglionic parasympathetic nerves of parotid glands. Such a "pharmacologically" decentralized gland was also found to have lost weight and to have developed a supersensitivity to chemical stimuli. All these phenomena are thought to be consequences of loss or reduction of secretory impulses from the central nervous system due to impaired ganglionic transmission.

References

Jan 1, 1976·Archives of Oral Biology·P Alm, J Ekström
Jul 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J Ekström
Sep 15, 1967·Experientia·P Ohlin, C Perec
Jan 1, 1963·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·I NORDENFELT

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