Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures

Neuroscience Letters
I M S SalesR M Freitas

Abstract

In the present study we investigated the alterations on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in rat striatum and frontal cortex caused by pilocarpine-induced seizures. Wistar rats were treated with 0.9% saline (i.p., control group), with the association of 0.9% saline (i.p.) plus pilocarpine (400mg/kg, i.p.), 30 min before of administration of saline (pilocarpine group). After the treatments all groups were observed for 1h. The ChAT and AChE activities were measured using spectrophotometric methods and the results compared to values obtained from saline-treated animals. In pilocarpine group was observed a significantly decreases in ChAT and AChE activities in striatum and frontal cortex of adult rats, when compared to control group. Results showed that during acute phase of seizures striatal and frontal cortex ChAT and AChE activities are diminished. Our findings suggest that seizures caused cognitive dysfunction and decreases of ChAT and AChE activities that might be related, at least in part, to the neurological problems presented by epileptic patients.

References

Dec 15, 1983·Experientia·W A TurskiL Turski
Jan 1, 1982·The Journal of Physiology·S Tucek
Jul 1, 1993·Progress in Neurobiology·J MassouliéF M Vallette
Apr 13, 2000·The European Journal of Neuroscience·M V FrantsevaP L Carlen
Jun 13, 2000·Alzheimer Disease and Associated Disorders·E Giacobini
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Bin LiOksana Lockridge
Apr 5, 2003·Neurochemical Research·Ezio Giacobini
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 9, 2005·The FEBS Journal·Rivelilson M FreitasMarta M F Fonteles
Jun 25, 2005·Current Alzheimer Research·Clive G BallardSultan Darvesh
Aug 9, 2005·The International Journal of Neuropsychopharmacology·Roger M LaneAlbert Enz
Jun 28, 2006·Cell and Tissue Research·Gabriel Zimmerman, Hermona Soreq

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