PMID: 9658289Jul 11, 1998Paper

Choline acetyltransferase expression during a putative developmental waiting period

The Journal of Comparative Neurology
D D SimmonsN B Mansdorf

Abstract

The relationship between the cholinergic expression, morphological development, and target cell innervation of olivocochlear (OC) efferent neurons was investigated in the postnatal hamster. Similar to what was found in previous studies, tracer injections into the contralateral cochlea labeled cells bodies retrogradely in periolivary regions and labeled cell bodies only rarely in the lateral superior olive (LSO). Few morphological differences were found among cell bodies labeled between postnatal day 1 (P1) and P30. Tracer injections into the crossed OC bundles within the brainstem anterogradely labeled terminals below the inner hair cells of the cochlea prior to P5 and labeled terminals below outer hair cells after P5, consistent with a period of transient innervation, as hypothesized previously. Within the superior olive, choline acetyltransferase (ChAT) was expressed differentially. In periolivary regions, ChAT was expressed as early as P0. ChAT-immunoreactive cell bodies in periolivary regions were similar morphologically to retrogradely labeled OC neurons. In contrast, within the LSO, ChAT was not expressed until after P2. Consistent with a medical OC projection to the cochlea at early postnatal ages, ChAT immunoreactivity ...Continue Reading

Citations

Oct 18, 2005·Journal of the Association for Research in Otolaryngology : JARO·Adam L BergeronDwayne D Simmons
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isabelle RouxElisabeth Glowatzki

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