PMID: 38851Jul 27, 1979

Choline and ethanolamine glycerophospholipid synthesis in isolated synaptosomes of rat brain

Biochimica Et Biophysica Acta
J StrosznajderL A. Horrocks

Abstract

Substantial activities of cholinephosphotransferase (EC 2.7.8.2) and ethanolaminephosphotransferase (EC 2.7.8.1) were found with lysed synaptosomes but not with intact synaptosomes isolated from adult rat brains. Synaptosomal and non-synaptosomal microsomal transferases were similar in kinetic properties. Substantial activities of synaptosomal transferases have not been described previously. Part of the glycerophospholipids in synaptosomal membranes may be synthesized in the nerve ending in addition to the glycerophospholipids supplied by axonal transport. The synthesis of the alkylacyl type of choline and ethanolamine glycerophospholipids was moderately inhibited by 1 mM ATP and 1 microM cyclic AMP. This synthesis was also inhibited by more than 50% by 1 mM norepinephrine and to a lesser extent by 5 mM hydroxytryptamine and 1 mM acetylcholine. Cyclic AMP may mediate the effects of biogenic amines. The relative synthesis of different glycerophospholipid classes and the relative proportion of alkylacyl type (plasmalogen precursors) and diacyl type of glycerophospholipids may be influenced by the levels of adenine nucleotides and/or biogenic amines. Elevated cyclic AMP levels will decrease the synthesis of plasmalogen precursors.

Citations

Jun 1, 1990·Molecular and Chemical Neuropathology·D S Damron, R V Dorman
May 1, 1995·Neurobiology of Aging·J E VanceD E Vance
Jun 17, 2000·Biochimica Et Biophysica Acta·J E VanceD E Vance
Mar 31, 1980·Brain Research·M H Kumara-Siri, R M Gould
Jul 13, 2004·Analytical Biochemistry·Hideki HayashiJ E Vance
Jan 1, 1989·Journal of Neurochemistry·M M Zaleska, D F Wilson
Dec 1, 1988·Journal of Cellular Physiology·B A LiptonB H Ginsberg
Jan 1, 1980·Journal of Neuroscience Research·E FimbresA K Percy
Aug 21, 2003·The Journal of Biological Chemistry·Jodi M CarterD E Vance

Related Concepts

Adenine Nucleotides
Brain
Diacylglycerol Cholinephosphotransferase
Ethanolaminephosphotransferase
Phosphatidylcholines
Phosphatidylethanolamines
Synaptosomes
Neurohormones

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