Choline deprivation: an overview of the major hepatic metabolic response pathways

Scandinavian Journal of Gastroenterology
Hussam Al-HumadiCharis Liapi

Abstract

Choline (Ch) is an important nutrient that is involved in many physiological functions. Deprivation of Ch (CD) may lead to hepatocellular modifications and/or even hepatic tumorigenesis and it can be a frequent problem in clinical settings; it can accompany various common pathological (alcoholism and malnutrition) or physiological states (pregnancy and lactation). The aim of this review is to provide an up-to-date overview of the major metabolic pathways involved in the hepatic response toward the experimentally or clinically induced CD, and to shed more light on the implicated (and probably interrelated) mechanisms responsible for the observed hepatocellular modifications and/or carcinogenesis.

References

Sep 1, 1975·The American Journal of Physiology·S J Robins
Sep 11, 1991·Biochimica Et Biophysica Acta·H OsmundsenJ I Pedersen
Jan 1, 1990·Nutrition and Cancer·P M NewberneJ L de Camargo
Feb 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Z M Yao, D E Vance
Jan 1, 1987·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·A E RogersP M Newberne
Jan 1, 1989·Free Radical Research Communications·S BanniV Vannini
Jan 1, 1988·Progress in Lipid Research·D E Vance, N D Ridgway
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M BestermanP Cuatrecasas
May 1, 1987·Carcinogenesis·N ChandarB Lombardi
Jan 1, 1981·Annual Review of Nutrition·S H Zeisel
Oct 1, 1994·Nutrition Reviews·D J Canty, S H Zeisel
Mar 1, 1995·The American Journal of Clinical Nutrition·A E Rogers
Jan 1, 1994·Annual Review of Nutrition·S H Zeisel, J K Blusztajn
Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C D AlbrightS H Zeisel
Feb 1, 1996·Journal of Hepatology·P LetteronD Pessayre
Feb 1, 1997·Clinical Science·R AlcoladoJ P Iredale
Mar 1, 1997·Virchows Archiv : an International Journal of Pathology·M L Hautekeete, A Geerts
Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M D WeltmanC Liddle
Apr 18, 1998·Gastroenterology·C P Day, O F James
Aug 26, 1998·Science·J K Blusztajn
Oct 9, 1998·The Journal of Biological Chemistry·C J WalkeyD E Vance
Jul 1, 1999·Molecular Pharmacology·D GründemannE Schömig
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Jul 25, 2000·Nutrition·S H Zeisel
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G VendemialeE Altomare
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K SoltysB Koneru
Aug 3, 2001·The Journal of Biological Chemistry·M Q Holmes-McNaryS H Zeisel
Sep 13, 2001·The Journal of Biological Chemistry·D H SweetJ B Pritchard
Nov 16, 2001·Biochemical Society Transactions·S ApparsundaramR D Blakely

❮ Previous
Next ❯

Citations

Mar 22, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Timea CsakGyongyi Szabo
Jul 19, 2018·Clinical and Experimental Pharmacology & Physiology·Hussam Al-HumadiCharis Liapi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jiannan SongSteven H Zeisel
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yona AvniRafael Bruck
Biochimica Et Biophysica Acta
Zhaoyu Li, Dennis E Vance
© 2021 Meta ULC. All rights reserved