PMID: 6108997Sep 1, 1980Paper

Choline high-affinity uptake and metabolism and choline acetyltransferase activity in the striatum of rats chronically treated with neuroleptics

Journal of Neurochemistry
F PedataG Pepeu

Abstract

High-affinity uptake of choline and choline acetyltransferase activity (ChAT) were measured in the striatum of rats treated for 45-60 days with haloperidol (1 mg/kg per os) and pimozide (1 mg/kg per os) daily and with fluspirilene (1 mg/kg i.m.) twice a week. Haloperidol and fluspirilene caused a 20%, and pimozide a 38%, increase in high-affinity uptake of choline. They also caused a significant decrease in ChAT activity: haloperidol, 20%; pimozide, 27%; and fluspirilene, 42%. In rats treated with fluspirilene for 65-80 days the metabolism of [3H] choline taken up by striatal synaptosomes was investigated. A 33% increase in total radioactivity, a significant increase in labelled acetylcholine (ACh), a relative decrease in labelled choline, and no change in labelled phosphorylcholine and betaine were found. It is concluded that the increase in high-affinity choline uptake caused by chronic administration of neuroleptic drugs is associated with a parallel increase in choline utilization for ACh formation. On the other hand, the decrease in ChAT activity does not appear to influence ACh formation.

References

Jul 7, 1967·Biochemical Pharmacology·L T Potter, W Murphy

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Citations

Dec 1, 1981·Cellular and Molecular Neurobiology·E Walum
Jun 1, 1988·Biological Psychiatry·S P MahadikS E Karpiak
Sep 16, 2010·Cancer Research·Xiaofeng XiaStephen T C Wong
Mar 13, 2012·Behavioral and Brain Functions : BBF·Pierre J BlanchetDaniel Lévesque
Nov 27, 2009·The Journal of Comparative Neurology·Yuko KataokaFlora M Vaccarino
Oct 1, 1983·Journal of Neurochemistry·A MesserP Maskin
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie C Licata, Perry F Renshaw
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alvin V TerrySahebarao P Mahadik
Feb 1, 1981·Pharmacological Research Communications·P Mantovani, G Pepeu

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