Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway.

Naunyn-Schmiedeberg's Archives of Pharmacology
Shu WangYan Liu

Abstract

Choline, an agonist of M(3) muscarinic acetylcholine receptors, is a precursor and metabolite of acetylcholine and is also a functional modulator of cellular membrane. However, the effect of choline on cardiac hypertrophy is not fully understood. The present study was therefore designed to explore whether choline could prevent cardiac hypertrophy induced by angiotensin II (Ang II) and clarify its potential mechanisms. Cardiac hypertrophy was induced by 0.6 mg kg(-1) day(-1) Ang II for 2 weeks in the presence or absence of choline pretreatment, while cardiomyocyte hypertrophy was induced by Ang II 0.1 μM for 48 h. We found that choline pretreatment attenuated the increment cell size of cardiomyocytes induced by Ang II both in vivo and in vitro. The high ANP and β-MHC levels induced by Ang II were also reversed by choline in cardiomyocytes. Meanwhile, choline pretreatment prevented the augment of reactive oxygen species (ROS) and intracellular calcium concentration in Ang II-treated cardiomyocytes. Furthermore, the upregulated phospho-p38 mitogen-activated protein kinase (MAPK) and calcineurin levels by Ang II in ventricular myocytes were attenuated by choline. In conclusion, choline prevents Ang II-induced cardiac hypertrophy th...Continue Reading

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Citations

Apr 30, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Cui-cui LuZhi-min Du
Mar 16, 2013·International Journal of Biological Sciences·Yilei ZhaoZhimin Du
Mar 19, 2014·International Journal of Cardiology·Cui LiHongli Shan
Sep 16, 2014·Molecular Medicine·Ashbeel RoyMarco A M Prado
Sep 16, 2018·Neuroscience Bulletin·Longzhu LiuWeijin Zang
Apr 2, 2020·Bioelectronic Medicine·A S CaravacaP S Olofsson

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