Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes

Advances in Nutrition
Jill L SherriffLeon A Adams

Abstract

Our understanding of the impact of poor hepatic choline/phosphatidylcholine availability in promoting the steatosis characteristic of human nonalcoholic fatty liver disease (NAFLD) has recently advanced and possibly relates to phosphatidylcholine/phosphatidylethanolamine concentrations in various, membranes as well as cholesterol dysregulation. A role for choline/phosphatidylcholine availability in the progression of NAFLD to liver injury and serious hepatic consequences in some individuals requires further elucidation. There are many reasons for poor choline/phosphatidylcholine availability in the liver, including low intake, estrogen status, and genetic polymorphisms affecting, in particular, the pathway for hepatic de novo phosphatidylcholine synthesis. In addition to free choline, phosphatidylcholine has been identified as a substrate for trimethylamine production by certain intestinal bacteria, thereby reducing host choline bioavailability and providing an additional link to the increased risk of cardiovascular disease faced by those with NAFLD. Thus human choline requirements are highly individualized and biomarkers of choline status derived from metabolomics studies are required to predict those at risk of NAFLD induced ...Continue Reading

References

Nov 1, 1967·The Tohoku Journal of Experimental Medicine·T NakamuraO Suzuki
Oct 1, 1982·The American Journal of Clinical Nutrition·G S Rosenberg, K L Davis
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden
Jul 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiannan SongSteven H Zeisel
Oct 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Martin KohlmeierSteven H Zeisel
Jan 10, 2006·The American Journal of Clinical Nutrition·Lori M SteadRené L Jacobs
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Jan 24, 2007·The Journal of Nutrition·Kelly T Williams, Kevin L Schalinske
May 11, 2007·The American Journal of Clinical Nutrition·Leslie M FischerSteven H Zeisel
Nov 17, 2007·The Journal of Infectious Diseases·Geraldine M McQuillanGustavo H Dayan
Jan 22, 2008·Journal of Lipid Research·Zhaoyu Li, Dennis E Vance
May 8, 2008·Current Opinion in Lipidology·Dennis E Vance
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca MieleAntonio Grieco
Nov 13, 2009·Nutrition Reviews·Steven H Zeisel, Kerry-Ann da Costa
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ShaSteven H Zeisel
Nov 10, 2010·The Journal of Biological Chemistry·Mary E ResseguieSteven H Zeisel
Dec 2, 2010·Nature Reviews. Gastroenterology & Hepatology·Lionel Hebbard, Jacob George
Jan 14, 2011·Annual Review of Medicine·Giovanni MussoMaurizio Cassader
Aug 24, 2011·Journal of Electron Microscopy·Michitaka SuzukiToyoshi Fujimoto
Aug 31, 2011·Critical Reviews in Clinical Laboratory Sciences·Briohny W Smith, Leon A Adams
Dec 3, 2011·Current Opinion in Gastroenterology·Karen D Corbin, Steven H Zeisel
Feb 18, 2012·The American Journal of Clinical Nutrition·Anthony L GuerrerioAnn O Scheimann
May 23, 2012·The Journal of Biological Chemistry·Jelske N van der VeenDennis E Vance
Apr 26, 2013·The New England Journal of Medicine·W H Wilson TangStanley L Hazen
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·René L JacobsDennis E Vance
Mar 29, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kerry-Ann da CostaSteven H Zeisel
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Felicity PayneDavid B Savage
Jun 20, 2014·The American Journal of Clinical Nutrition·Carolyn A MillerSteven H Zeisel
Jul 16, 2014·World Journal of Gastroenterology : WJG·Otto Kucera, Zuzana Cervinkova

❮ Previous
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Citations

Sep 7, 2017·European Journal of Nutrition·Fabiana de Faria GhettiAna Paula Boroni Moreira
May 12, 2018·Nature Reviews. Gastroenterology & Hepatology·Anupriya TripathiRob Knight
Jul 27, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinichiro MinamiKatsunori Iijima
Dec 24, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Åke Nilsson, Rui-Dong Duan
Apr 26, 2019·Nutrients·Yasmine ProbstElizabeth Neale
Aug 25, 2020·Langenbeck's Archives of Surgery·Benedikt KaufmannDaniel Hartmann
Mar 16, 2019·Experimental Biology and Medicine·Tien S Dong, Jonathan P Jacobs
Aug 8, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Gemma AragonèsTeresa Auguet
Sep 13, 2019·Metabolites·Maria Guarino, Jean-François Dufour
May 27, 2020·Veterinary Medicine International·Andrea MarchegianiMatteo Cerquetella
Jan 9, 2019·Hepatology Communications·Suzanne R SharptonSusan V Lynch
Apr 16, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Uday C GhoshalEamonn M M Quigley
Oct 24, 2019·Journal of Translational Medicine·Haya Al-SulaitiNayef A Mazloum
Jan 15, 2020·Pharmaceutical Medicine·Somaya Albhaisi, Arun J Sanyal
Aug 9, 2020·Frontiers in Immunology·Yongyan Chen, Zhigang Tian
Nov 21, 2018·Nature Microbiology·Carina L ChittimEmily P Balskus
Mar 11, 2020·International Journal of Molecular Sciences·Xiaodong TanJie Wen
Nov 5, 2020·Critical Reviews in Analytical Chemistry·Jie Tang Han Han
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Katherine Jp SchwengerJohane P Allard
Feb 9, 2020·Gastroenterology Clinics of North America·Manu V ChakravarthyNicola Guess
Jan 29, 2021·World Journal of Gastroenterology : WJG·Delfin Gerard BuycoRotonya Carr
Apr 18, 2018·International Journal of Biological Macromolecules·Nasrin Nikzad, Zahra Karami
Apr 4, 2021·Nutrients·Andreas Blesl, Vanessa Stadlbauer
May 14, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Patrizia BurraUNKNOWN Special Interest Group Gender in Hepatology of the Italian Association for the Study of the Liver (AISF)
Jun 3, 2021·International Journal of Molecular Sciences·Farha RamzanRichard F Mithen

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