Choline may be an essential nutrient in malnourished patients with cirrhosis

Gastroenterology
R K ChawlaH L Bonkovsky

Abstract

Elemental diets designed for nutritional support in protein-calorie malnutrition are often deficient in choline, a nonessential nutrient. Previously, malnourished patients on these diets were found to be at risk of developing plasma choline deficiency. We have now estimated the prevalence of this deficiency by determining fasting plasma levels of choline among cirrhotic and noncirrhotic malnourished male subjects maintained on regular hospital mixed food or elemental parenteral and enteral formulas. Plasma choline concentrations (microM, average +/- SD) were as follows: (i) mixed foods, 11.3 +/- 4.3 for cirrhotic (n = 22) and 9.3 +/- 2.4 for noncirrhotic (n = 12) patients; (ii) parenteral formula, 5.3 +/- 1.6 for cirrhotic (n = 5) and 8.6 +/- 5.2 for noncirrhotic (n = 16) subjects; and (iii) enteral formula, 6.1 +/- 1.2 for cirrhotic (n = 5) and 11.7 +/- 1.9 for noncirrhotic (n = 4) subjects. The level for healthy normal subjects eating mixed foods was 12.0 +/- 2.2. The prevalence of plasma choline deficiency, i.e., plasma levels greater than or equal to 2 SD below the normal average, was as follows: parenteral formula, all cirrhotic and 10 of 16 noncirrhotic subjects; enteral formula, all cirrhotic and none of the noncirrhotic...Continue Reading

Citations

Oct 1, 1992·Journal of the American College of Nutrition·S H Zeisel
Oct 11, 2007·Journal of Gastroenterology and Hepatology·Sona SaksenaRakesh Kumar Gupta
Feb 13, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Ashish VermaRakesh Kumar Gupta
Jan 11, 2013·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Jan 27, 2019·Journal of Inherited Metabolic Disease·Saskia B Wortmann, Johannes A Mayr
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K C TrimbleD G Weir
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·H TsukamotoR Thurman
Jun 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Anthony L GuerrerioAnn O Scheimann
Jan 13, 2000·Pathology International·D Nakae
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden
Jan 1, 2008·Magnetic Resonance Insights·A HudaM A Thomas
Sep 1, 1991·Gut·D B SilkC Wicks
Oct 7, 2000·Journal of the American College of Nutrition·S H Zeisel
Feb 18, 2012·The American Journal of Clinical Nutrition·Anthony L GuerrerioAnn O Scheimann
Jun 3, 2005·The Journal of Nutrition·Giulio MarchesiniGiampaolo Bianchi
Jul 25, 2000·Nutrition·S H Zeisel
Jan 1, 1996·Life Sciences·J J Freeman
Aug 7, 2002·Alcohol·Craig J McClainShirish Barve
Jul 1, 1990·The Journal of Nutritional Biochemistry·S H Zeisel
Jun 1, 1997·Journal of the American Dietetic Association·E P Shronts
Oct 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G MarchesiniE Pisi
Nov 27, 2004·Journal of the American Dietetic Association·Marjorie G BusbySteven H Zeisel
Sep 1, 1993·Baillière's Clinical Gastroenterology·C S Lieber
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Aug 10, 2010·Journal of Proteome Research·Beatriz JiménezVicente Felipo

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