Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.

Nutrients
Emma Derbyshire, Rima Obeid

Abstract

The foundations of neurodevelopment across an individual's lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function. Of these, evidence for choline has been building but has not been widely collated using systematic approaches. Therefore, a systematic review was performed to identify the animal and human studies looking at inter-relationships between choline, neurological development, and brain function during the first 1000 days of life. The database PubMed was used, and reference lists were searched. In total, 813 publications were subject to the title/abstract review, and 38 animal and 16 human studies were included after evaluation. Findings suggest that supplementing the maternal or child's diet with choline over the first 1000 days of life could subsequently: (1) support normal brain development (animal and human evidence), (2) protect against neural and metabolic insults, particularly when the fetus is exposed to alcohol (animal and human evidence), and (3) improve neural and cognitive functioning (animal evidence). Overall, most offspring would benefit from increased choline supply during th...Continue Reading

References

Oct 1, 1976·Life Sciences·J J Freeman, D J Jenden
Feb 13, 1976·Science·E L Cohen, R J Wurtman
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Sep 15, 1981·The Biochemical Journal·S H Zeisel, R J Wurtman
Nov 1, 1980·Neurology·S H ZeiselM Logue
Feb 9, 1994·Biochemical Pharmacology·E M van der AaF G Russel
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 18, 1997·Brain Research. Developmental Brain Research·M Q Holmes-McNaryS H Zeisel
Jul 13, 2001·Biochemical Pharmacology·C IkonomidouJ W Olney
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C L YenS H Zeisel
Jan 18, 2003·Archives of Physiology and Biochemistry·Y Ozarda IlcolI H Ulus
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden
Nov 11, 2003·The Journal of Nutrition·Corneliu N CraciunescuSteven H Zeisel
Jul 6, 2004·American Journal of Epidemiology·Gary M ShawDonna M Schaffer
Jan 11, 2005·Journal of the American College of Nutrition·Steven H Zeisel
May 6, 2006·Nutrition Reviews·Steven H Zeisel, Mihai D Niculescu
Jul 20, 2006·Annual Review of Nutrition·Steven H Zeisel
Aug 19, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S Jill JamesDavid W Gaylor
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Apr 11, 2008·The American Journal of Clinical Nutrition·Caroline SignoreJames L Mills
Jul 14, 2009·Epidemiology·Gary M ShawPer M Ueland
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 16, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mihai G MehedintSteven H Zeisel
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mihai G MehedintSteven H Zeisel
Jul 27, 2010·Journal of the American Dietetic Association·Marie A Caudill
Aug 14, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer D ThomasHector D Dominguez
Apr 27, 2011·Journal of Autism and Developmental Disorders·Stepan MelnykS Jill James
Jun 23, 2011·Seminars in Cell & Developmental Biology·Steven H Zeisel
Apr 10, 2012·Central Nervous System Agents in Medicinal Chemistry·Jan Krzysztof Blusztajn, Tiffany J Mellott
Apr 19, 2012·Alcoholism, Clinical and Experimental Research·Nicha K H OteroSandra J Kelly
Jun 13, 2012·Paediatric and Perinatal Epidemiology·Eduardo VillamorEmily Oken
Aug 25, 2012·Pharmacology, Biochemistry, and Behavior·Jennifer A Corriveau, Melissa J Glenn
Dec 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinyin JiangMarie A Caudill
Jan 15, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Jan Krzysztof Blusztajn, Tiffany J Mellott
Jan 16, 2013·The American Journal of Psychiatry·Randal G RossRobert Freedman
Feb 22, 2013·American Journal of Epidemiology·Caroline E BoekeEmily Oken

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Citations

Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi-Chen YuanXue-Ying Mao
Jun 3, 2021·Nutrients·Victoria Arija, Josefa Canals
May 25, 2021·Clinical Nutrition ESPEN·M Camille HoffmanSharon K Hunter
Jun 12, 2021·The American Journal of Clinical Nutrition·Mônica A BatalhaGilberto Kac
Aug 28, 2021·International Journal of Molecular Sciences·Samantha D Francis Stuart, Alice R Villalobos
Oct 7, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Mengyuan MiaoChongke Zhong
Oct 31, 2021·Alcoholism, Clinical and Experimental Research·Jennifer D Thomas

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