Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats.

Nutrients
Jaylyn WaddellSandra M Mooney

Abstract

Fetal alcohol spectrum disorder (FASD) is the leading known cause of intellectual disability, and may manifest as deficits in cognitive function, including working memory. Working memory capacity and accuracy increases during adolescence when neurons in the prefrontal cortex undergo refinement. Rats exposed to low doses of ethanol prenatally show deficits in working memory during adolescence, and in cognitive flexibility in young adulthood. The cholinergic system plays a crucial role in learning and memory processes. Here we report that the combination of choline and training on a working memory task during adolescence significantly improved cognitive flexibility (performance on an attentional set shifting task) in young adulthood: 92% of all females and 81% of control males formed an attentional set, but only 36% of ethanol-exposed males did. Resting state functional magnetic resonance imaging showed that functional connectivity among brain regions was different between the sexes, and was altered by prenatal ethanol exposure and by choline + training. Connectivity, particularly between prefrontal cortex and striatum, was also different in males that formed a set compared with those that did not. Together, these findings indica...Continue Reading

References

Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·P W KodituwakkuS D Handmaker
Dec 28, 1999·Brain Research. Developmental Brain Research·W H Meck, C L Williams
Jun 2, 2001·Developmental Neuropsychology·P D ConnorA P Streissguth
Oct 3, 2003·Neurobiology of Learning and Memory·Michael E Ragozzino
Dec 4, 2003·Behavioural Brain Research·Kerry McAlonan, Verity J Brown
Jan 30, 2004·Learning & Memory·Michael E Ragozzino, Daniel Choi
Feb 22, 2005·Neurobiology of Learning and Memory·Jenna Kim, Michael E Ragozzino
Jan 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mihai D NiculescuSteven H Zeisel
Jun 28, 2006·Cerebral Cortex·Pernille J OlesenTorkel Klingberg
Dec 19, 2007·Behavioral Neuroscience·Steven L YoungentobLisa M Youngentob
Jul 1, 2008·NeuroImage·Elizabeth D O'HareElizabeth R Sowell
Oct 31, 2008·Journal of Neurophysiology·Charles F GeierBeatriz Luna
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory B BissonetteElizabeth M Powell
Sep 5, 2009·Developmental Disabilities Research Reviews·Piyadasa W Kodituwakku
Sep 16, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mihai G MehedintSteven H Zeisel
Oct 9, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cherie L Marvel, John E Desmond
Nov 13, 2009·Nutrition Reviews·Steven H Zeisel, Kerry-Ann da Costa
Jan 1, 2010·Social Cognitive and Affective Neuroscience·Craig M BennettMichael B Miller
Jun 22, 2010·Neuropsychology Review·Cherie L Marvel, John E Desmond
Nov 16, 2010·Alcoholism, Clinical and Experimental Research·Sandra W JacobsonJoseph L Jacobson
Jul 28, 2011·Alcoholism, Clinical and Experimental Research·Bruce S SpottiswoodeSandra W Jacobson
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·P Christoph JanieschIleana L Hanganu-Opatz
Jan 26, 2012·Frontiers in Neuroinformatics·Pedro Antonio Valdés-HernándezRyuta Kawashima
Jun 8, 2012·The European Journal of Neuroscience·E Alexander ChaseVerity J Brown
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Philip A MaySoraya Seedat
Apr 16, 2013·Neuropharmacology·Hanna S LindgrenStephen B Dunnett
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Theodore D SatterthwaiteRaquel E Gur
Dec 21, 2013·Behavioural Brain Research·Elena I Varlinskaya, Sandra M Mooney
Jul 11, 2014·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Kelly NashJoanne Rovet
Aug 8, 2014·Neuron·Samuel S-H WangAleksandra Badura
Nov 15, 2014·Human Brain Mapping·Jessica A BernardVijay A Mittal
Jan 13, 2015·Alcoholism, Clinical and Experimental Research·Kristin MarquardtJonathan L Brigman
Apr 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Duncan E AstleMark W Woolrich
Jul 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah L HawesKim T Blackwell
Oct 9, 2015·The American Journal of Clinical Nutrition·Jeffrey R WozniakMichael K Georgieff
Jan 8, 2016·Journal of Cognitive Neuroscience·Todd W ThompsonJohn D E Gabrieli
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie

❮ Previous
Next ❯

Citations

Jun 22, 2021·Frontiers in Molecular Neuroscience·Bonnie AlberryShiva M Singh

❮ Previous
Next ❯

Software Mentioned

ClustSim
AFNI
StrDM

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.