PMID: 16636297Apr 26, 2006Paper

Choline transport for phospholipid synthesis

Experimental Biology and Medicine
Vera MichelMarica Bakovic

Abstract

Choline is an essential nutrient for all cells because it plays a role in the synthesis of the membrane phospholipid components of the cell membranes, as a methyl-group donor in methionine metabolism as well as in the synthesis of the neurotransmitter acetylcholine. Choline deficiency affects the expression of genes involved in cell proliferation, differentiation, and apoptosis, and it has been associated with liver dysfunction and cancer. Abnormal choline transport and metabolism have been implicated in a number of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Therefore, the study of choline transport and the characteristics of choline transporters are of central importance to understanding the mechanisms that underlie membrane integrity and cell signaling in such disorders. Kinetic studies with radiolabeled choline and inhibitors distinguish three systems for choline transport: (i) low-affinity facilitated diffusion, (ii) high-affinity, Na+-dependent transport, and (iii) intermediate-affinity, Na+-independent transport. It is only recently, however, that the proteins having transport characteristics of at least one of these systems have been identified. They include (i) polyspecific organic cation t...Continue Reading

References

May 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A Barbeau
Feb 1, 1975·The American Journal of Physiology·M Acara
Oct 1, 1992·Journal of the American College of Nutrition·S H Zeisel
Dec 1, 1992·The American Journal of Physiology·A B FisherA Kleinzeller
Mar 1, 1992·Journal of Neurochemistry·J KleinJ Schmitthenner
Jun 1, 1990·Annals of Neurology·B V ManyamJ A Colliver
Aug 27, 1986·Brain Research·P R Lowenstein, J T Coyle
Dec 1, 1986·Journal of Applied Physiology·R W YostA B Fisher
Feb 10, 1986·Life Sciences·B L MillerD F Benson
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Aug 24, 1995·Biochemical and Biophysical Research Communications·J M CancelaA Beley
Jan 1, 1994·Annual Review of Nutrition·S H Zeisel, J K Blusztajn
Aug 24, 1994·Biochimica Et Biophysica Acta·S M Grassl
Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C D AlbrightS H Zeisel
Jul 16, 1996·Biochemical and Biophysical Research Communications·M OkudaK Inui
Mar 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M R KoehlerM Schmid
Oct 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N Schweifer, D P Barlow
Aug 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·F MartelE Schömig
Dec 20, 1996·The Journal of Biological Chemistry·A E BuschH Koepsell
Mar 1, 1997·Journal of Neurochemistry·V VogelsbergM Hadjiconstantinou
Jul 1, 1997·Molecular and Cellular Biology·S F SellsV M Rangnekar
Jul 1, 1997·DNA and Cell Biology·V GorboulevH Koepsell
Nov 5, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S P RileyB M Hendry
Nov 25, 1997·Biochimica Et Biophysica Acta·C R McMaster, R M Bell
Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Jan 24, 1998·The Journal of Biological Chemistry·G NagelH Koepsell
Apr 7, 1998·Biochimica Et Biophysica Acta·S TerashitaK M Giacomini
Apr 16, 1998·The Journal of Membrane Biology·G D van Rossum, C A Boyd

❮ Previous
Next ❯

Citations

Oct 11, 2007·Journal of the Association for Research in Otolaryngology : JARO·P K KommareddiT E Carey
Jun 21, 2008·Histochemistry and Cell Biology·W KummerU Pfeil
Jan 31, 2009·The Journal of Pharmacology and Experimental Therapeutics·Amber DahlinJoanne Wang
Feb 18, 2010·Biomarkers in Medicine·Andrea L Merz, Natalie J Serkova
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William E WuOded Gonen
Jun 26, 2012·Immunological Reviews·Peder S OlofssonKevin J Tracey
Nov 20, 2012·Journal of Bacteriology·Claudia K HerrmannDiego J Comerci
Mar 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Motoyuki KohjimaMakoto Nakamuta
Apr 12, 2016·Chemistry : a European Journal·Evelyn KuahZhiqiang Gao
May 11, 2016·Circulation. Cardiovascular Imaging·Jakub Toczek, Mehran M Sadeghi
Sep 16, 2016·Frontiers in Pharmacology·Oxana DobrovinskayaIgor Pottosin
Aug 30, 2020·Pharmaceutical Research·Kandarp M DaveDevika S Manickam
Sep 7, 2007·Acta Biochimica Et Biophysica Sinica·Tao WangJianren Gu
Jun 18, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Dominique SlaetsFilip De Vos
Sep 24, 2009·Metabolomics : Official Journal of the Metabolomic Society·Ahmet T BaykalHong Li
Oct 19, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·April M ChowEd X Wu
Apr 25, 2013·Journal of Gastroenterology·Yuki OhishiUNKNOWN PBC Study Group of NHOSLJ
Jan 23, 2014·Breast Cancer Research : BCR·Maria T GrindeIngrid S Gribbestad
Jan 29, 2013·Critical Reviews in Biochemistry and Molecular Biology·Neale D Ridgway
Oct 19, 2013·Journal of Lipid Research·Craig C MortonNeale D Ridgway
Oct 10, 2018·European Journal of Nutrition·Wolfgang BernhardAxel R Franz
Nov 22, 2018·American Journal of Physiology. Cell Physiology·Yuri OkazakiNoriyuki Yanaka
Mar 21, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Takashi TanakaAkira Kawashima
Dec 11, 2019·Nutrients·Rola A Bekdash
Dec 13, 2019·Journal of Refractive Surgery·Esat CinarGökhan Erbakan
Jan 23, 2020·Viruses·Kaelan Gobeil OdaiMorgan D Fullerton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.