Cholinergic activation of Cl- secretion in rat colonic epithelia

European Journal of Pharmacology
K E O'MalleyA W Baird

Abstract

Acetylcholine receptor agonists and antagonists were used in a pharmacological analysis to identify which muscarinic receptor(s) may be involved in cholinergic regulation of Cl- secretion across rat colonic mucosa in vitro. A comparative ligand binding analysis for each of the antagonists was carried out in parallel. Both studies elicited identical rank order potencies (atropine > or = 4-diphenyl-acetoxy-N-piperidine methiodide (4-DAMP) > pirenzepine > 11-[[2[(diethylamino)methyl]-1-pipiridinyl]acetyl[5,11- dihydro-6H-pyrido[2,3-b]]1,4]benzodiazepine-6-one (AF-DX 116). Cholinomimetic-induced Cl- secretion was predominantly mediated by activation of muscarinic receptors in rat isolated colonic mucosa, with only a modest contribution from nicotinic receptors. Short circuit current responses evoked by the selective muscarinic M1 receptor agonist 4-[[(3-chlorophenyl)amino]carbonyl]-N,N,N-trimethyl-2-butyn-1-a minium chloride (McN-A-343) suggest that this receptor subtype, which is thought to be neuronally sited, also plays a minor role in regulation of intestinal ion transport. The principal epithelial cell receptors responsible for acetylcholine receptor-mediated Cl- secretion appear to belong to the M3 class.

References

Aug 1, 1978·The Journal of Physiology·J G BrowningJ S Redfern
Oct 12, 1989·The New England Journal of Medicine·R K Goyal
Feb 1, 1986·The Journal of Clinical Investigation·K Dharmsathaphorn, S J Pandol
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·H Kilbinger, M Nafziger
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T J Rimele, T S Gaginella
Jan 12, 1981·Life Sciences·E J Tapper, D L Lewand
Jun 1, 1993·British Journal of Pharmacology·U KachintornK E Barrett
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

❮ Previous
Next ❯

Citations

Jun 27, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O YamamotoJ Yano
Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·I WesslerK Racké
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·M MatsuiM M Taketo
Nov 1, 1995·British Journal of Pharmacology·C T Taylor, A W Baird
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·S A Przyborski, R J Levin
Mar 13, 2001·Japanese Journal of Pharmacology·I WesslerC J Kirkpatrick
Dec 6, 2005·The Japanese Journal of Physiology·A KokuboK Kawahara
Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·Christina L Hirota, Derek M McKay
May 31, 2012·Pharmacology & Therapeutics·Frederick J Mitchelson
Aug 27, 2004·Acta Physiologica Scandinavica·R LarsenA Mertz-Nielsen
Sep 19, 2006·British Journal of Pharmacology·C L Hirota, D M McKay
Jan 13, 2006·European Journal of Pharmacology·Rainer HaberbergerMartin Diener
Feb 12, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M HarringtonB R Southwell
Aug 22, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H M MohanA W Baird
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Jayaraman LakshmananMichael G Ross
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·I K Wessler, C J Kirkpatrick
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Henri DubocMuriel Larauche
Apr 23, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·M Pelissier-RotaM R Jacquier-Sarlin
Jun 19, 2008·Pharmacology & Therapeutics·Neil M Nathanson
Mar 8, 2018·International Journal of Molecular Sciences·Atsukazu KuwaharaYoshinori Marunaka
May 5, 2004·Experimental Physiology·T PriorP K Rangachari
Oct 13, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John P RussellBeverley Greenwood-Van Meerveld
Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hisayoshi HayashiYuichi Suzuki
Aug 13, 1999·The American Journal of Physiology·J SantosM H Perdue
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M B GillinghamD M Ney
Aug 4, 1998·The American Journal of Physiology·C S ChewG Flemström
Jan 18, 2011·The Journal of Pharmacy and Pharmacology·Seung Il JeongKyu Yong Jung
Dec 9, 1998·The American Journal of Physiology·M MallK Kunzelmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.