Cholinergic and Adenosinergic Modulation of Synaptic Release.

Neuroscience
Danqing YangDirk Feldmeyer

Abstract

In this review we will discuss the effect of two neuromodulatory transmitters, acetylcholine (ACh) and adenosine, on the synaptic release probability and short-term synaptic plasticity. ACh and adenosine differ fundamentally in the way they are released into the extracellular space. ACh is released mostly from synaptic terminals and axonal bouton of cholinergic neurons in the basal forebrain (BF). Its mode of action on synaptic release probability is complex because it activate both ligand-gated ion channels, so-called nicotinic ACh receptors and G-protein coupled muscarinic ACh receptors. In contrast, adenosine is released from both neurons and glia via nucleoside transporters or diffusion over the cell membrane in a non-vesicular, non-synaptic fashion; its receptors are exclusively G-protein coupled receptors. We show that ACh and adenosine effects are highly specific for an identified synaptic connection and depend mostly on the presynaptic but also on the postsynaptic receptor type and discuss the functional implications of these differences.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O D UchitelR Llinás
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A Prince, C F Stevens
Sep 1, 1991·The Journal of Physiology·N LerescheV Crunelli
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M V Tsodyks, H Markram
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
May 1, 1997·Trends in Neurosciences·L G Wu, P Saggau
Feb 17, 1998·Trends in Neurosciences·D M Kullmann, F Asztely
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·L G WuB Sakmann
Apr 9, 1999·Nature Neuroscience·A ReyesB Sakmann
May 14, 1999·Trends in Pharmacological Sciences·M ZoliK Fuxe
Jul 22, 1999·Annals of the New York Academy of Sciences·K A RadcliffeJ A Dani
Feb 17, 2000·Trends in Neurosciences·J D Clements, R A Silver
Apr 3, 2001·Annual Review of Neuroscience·T V Dunwiddie, S A Masino
Feb 19, 2002·The Journal of Physiology·Tomoko Takigawa, Christian Alzheimer
Nov 16, 2002·The Journal of Physiology·David Fernández de SevillaWashington Buño
Feb 7, 2003·Current Topics in Medicinal Chemistry·Bertil B FredholmPer Svenningsson

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Citations

Feb 9, 2021·Neuroscience·David Fernández de SevillaWashington Buño
Jan 23, 2021·International Journal of Molecular Sciences·Stephanie GraserFranz Jakob
Jan 10, 2022·Neuroscience·Kevin C GonzalezAdrian Negrean

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