Cholinergic and dopaminergic mechanisms involved in the recovery of circadian anticipation by aniracetam in aged rats

Pharmacology, Biochemistry, and Behavior
Yushiro TanakaKazuo Nakamura

Abstract

We have reported that repeated administration of aniracetam (100 mg/kg p.o.) for 7 consecutive days recovers mealtime-associated circadian anticipatory behavior diminished in aged rats. The present study examines the mode of action underlying the restoration by aniracetam with various types of receptor antagonists. Coadministration of scopolamine (0.1 mg/kg i.p.) or haloperidol (0.1 mg/kg i.p.) for the last 3 days significantly reduced the restorative effects of aniracetam without affecting the timed feeding-induced anticipatory behavior by each receptor antagonist itself. The other receptor antagonists, mecamylamine (3 mg/kg i.p.), 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX, 1 microg/rat i.c.v.) had no effect on either the basal or aniracetam-elicited circadian anticipation. In contrast, ketanserin (1 mg/kg i.p.) itself recovered the diminished anticipatory behavior as aniracetam did, but it did not alter the restorative effects of aniracetam. Among the receptor antagonists tested, NBQX reduced appetite and haloperidol induced circadian hypoactivity. These results suggest that the food-entrainable circadian oscillations or the temporal regulatory system of behavior is modulated by cholinergic, dopaminergic and...Continue Reading

References

Nov 1, 1990·Neurobiology of Aging·R E MistlbergerM C Moore-Ede
Nov 1, 1987·Neurochemical Research·A MorettiF Trunzo
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·D G Morgan
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S Armstrong
Jun 6, 1980·Science·T G HeffnerL S Seiden
Jan 1, 1994·Brain Research. Brain Research Reviews·L P Morin
May 1, 1994·Physiology & Behavior·S ShibataS Watanabe
May 1, 1994·Dementia·C G GottfriesA Wallin
Oct 8, 1999·European Journal of Pharmacology·K Nakamura, M Shirane
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·Y TanakaK Nakamura
Feb 24, 2001·Psychiatry and Clinical Neurosciences·M KimuraS Inoué
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·K Nakamura, M Kurasawa
Jun 20, 2001·European Journal of Pharmacology·K Nakamura, M Kurasawa
Nov 10, 2001·Psychopharmacology·K Nakamura, Y Tanaka

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