Cholinergic anti-inflammatory pathway and its role in treatment of sepsis

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Shuangfeng ZiFurong Liu

Abstract

The cholinergic anti-inflammatory pathway (CAP) is a neuro-immunomodulatory pathway,in which acetylcholine (ACh) released by the interaction of vagal nerves with α7 nicotinic acetylcholine receptor (α7nAChR),which prevents the synthesis and release of pro-inflammatory cytokines and ultimately regulates the local or systemic inflammatory response in a feedback manner. It has been shown that there are many possible effective treatments for sepsis, including vagus nerve stimulation by physical therapy, drugs such as acetylcholine receptor agonist and ultrasound therapy.

Citations

Sep 24, 2020·Pulmonary Medicine·Askin GülsenOguz Kilinc
May 4, 2021·Frontiers in Immunology·Namrita Halder, Girdhari Lal
May 25, 2021·Frontiers in Medicine·Eric AzabouDjillali Annane

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