PMID: 1194448Jul 11, 1975Paper

Cholinergic blockade, septal lesions, and DRL performance in the rat

Journal of Comparative and Physiological Psychology
P EllenJ M Stahl

Abstract

Four experiments describing the effects of cholinergic blockade produced by systemic injection of either atropine sulfate or atropine methyl nitrate on the differential reinforcement of low rate (DRL) responding of rats are reported. It was shown that atropine sulfate injected either chronically or at high dosage suppressed DRL responding. Injected acutely, atropine sulfate produced disinhibitory effects. When atropine was injected either chronically or acutely into animals with septal lesions, there was suppression of responding. It was suggested that the specific behavioral outcome resulting from cholinergic blockade depends on the balance resulting from the competing peripheral and central effects of such blockade.

Citations

Jul 1, 1989·Neuroscience and Behavioral Physiology·T A Mering
Jan 1, 1992·Psychopharmacology·M Soffié, H Lejeune
Oct 1, 1977·Physiology & Behavior·R H Myers, J M De Castro
Jul 1, 1982·Pharmacology, Biochemistry, and Behavior·J H McDonough
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·S B McMaster, J M Carney
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·W F Liu, J M Beaton
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·S B McMaster, J M Carney
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J A Gray, N McNaughton

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