Cholinergic changes in the hippocampus of stroke-prone spontaneously hypertensive rats

Stroke; a Journal of Cerebral Circulation
H TogashiH Saito

Abstract

We investigated age-related changes in the central cholinergic systems in stroke-prone spontaneously hypertensive rats (SHRSP) to examine whether the regional and progressive cholinergic changes occur and are correlated with behavioral changes in the passive avoidance task. Tissue levels of choline (Ch) and acetylcholine (ACh) were determined in the cerebral regions, including the hippocampus, of SHRSP (at two ages: 15 to 20 and 30 to 40 weeks) that had been tested in a passive avoidance task and were compared with those of age-matched controls, Wistar-Kyoto rats (WKY). With the use of in vivo microdialysis, high K+-stimulated release of hippocampal ACh, a functional parameter of the cholinergic system, was also determined in 15- to 20-week-old SHRSP. We found that 15- to 20-week-old SHRSP demonstrated a markedly lower level of hippocampal Ch than age-matched WKY. The decrease in the Ch level in 15- to 20-week-old SHRSP was observed in all regions examined; however, in the hippocampus a significant difference from WKY was subsequently observed at the age of 30 to 40 weeks. The hippocampal ACh release was markedly decreased by repetitive stimulation with high K+ in 15- to 20-week-old SHRSP. Behavioral impairment in the passive a...Continue Reading

References

Jul 1, 1977·Japanese Heart Journal·I AkiguchiC Kawai
Jul 1, 1977·Japanese Heart Journal·I AkiguchiC Kawai
May 1, 1989·Acta Neurologica Scandinavica·A WallinB Winblad
Sep 1, 1988·Japanese Journal of Pharmacology·N NakaharaG Kawanishi
Jan 1, 1983·Neurobiology of Aging·C G GottfriesB Winblad
Jul 30, 1982·Science·R T BartusA S Lippa
Feb 1, 1980·Age and Ageing·E K Perry

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Citations

Apr 7, 2007·Bulletin of Experimental Biology and Medicine·L V LoskutovaA L Markel'
Nov 11, 2009·Bulletin of Experimental Biology and Medicine·L V Loskutova, N V Kostjunina
Feb 19, 2005·Current Psychiatry Reports·Gustavo C Román
Oct 8, 1999·European Journal of Pharmacology·K Nakamura, M Shirane
Nov 6, 2002·Journal of the Neurological Sciences·Raj Kalaria
Nov 6, 2002·Journal of the Neurological Sciences·C Grantham, H Geerts
Sep 3, 2010·Drugs & Aging·Dina Zekry, Gabriel Gold
Dec 21, 2002·Acta Neurologica Scandinavica. Supplementum·T Erkinjuntti
Jun 9, 2005·Expert Review of Neurotherapeutics·Gustavo C Román
Apr 12, 2007·Expert Opinion on Pharmacotherapy·Rita MorettiGilberto Pizzolato
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Francesco AmentaDaniele Tomassoni
Sep 29, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Emma L BaileyJoanna M Wardlaw
Dec 3, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A F KurzC R Venkata Damaraju
Aug 25, 2010·Journal of Neurochemistry·Nadim S JiwaAtticus H Hainsworth
Nov 23, 2005·Neurobiology of Aging·Gustavo C Román, Raj N Kalaria
Nov 19, 2005·Mechanisms of Ageing and Development·Seyed Khosrow Tayebati
May 28, 2004·Expert Opinion on Pharmacotherapy·Rita MorettiAntonio Bava
Feb 13, 2001·Methods : a Companion to Methods in Enzymology·J C DayR Quirion
Jun 26, 2012·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Jan 7, 2005·American Journal of Alzheimer's Disease and Other Dementias·Rita MorettiGiuseppe Cazzato
Oct 23, 2003·American Journal of Alzheimer's Disease and Other Dementias·Rita MorettiAntonio Bava
Feb 13, 2020·International Journal of Molecular Sciences·Rita Moretti, Paola Caruso
Nov 19, 2019·Neural Plasticity·Benjamin Maïer, Nathalie Kubis
Dec 21, 2002·Acta Neurologica Scandinavica. Supplementum·A Kurz
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Francesco AmentaDaniele Tomassoni
Dec 15, 2020·Trends in Neurosciences·Sophie QuickAnna Williams

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