Nov 15, 2019

Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M Gersel StokholmNicola Pavese

Abstract

Cholinergic dysfunction appears to play a role in the cognitive impairment observed in Parkinson's disease and dementia with Lewy bodies. The occurrence of cholinergic dysfunction in the early stages of these conditions, however, has not been investigated. The objective of this study was to investigate cholinergic function in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD), a disorder recognized to be an early stage of both Parkinson's disease and dementia with Lewy bodies. A total of 21 patients with polysomnography-confirmed iRBD with no evidence of parkinsonism and cognitive impairment and 10 controls underwent positron emission tomography (PET) to assess brain acetylcholinesterase levels (11 C-donepezil PET) and nigrostriatal dopaminergic function (18 F-DOPA PET). Clinical examination included the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III, Mini Mental State Examination and Montreal Cognitive Assessment. The 11 C-donepezil PET was successfully performed in 17 patients with iRBD and nine controls. Compared with controls, patients with iRBD showed a mean 7.65% reduction in neocortical 11 C-donepezil levels (P = 0.005). Bilateral superior temporal cortex, occipital c...Continue Reading

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Citations

Mentioned in this Paper

Unified Parkinson's Disease Rating Scale Questionnaire
Study
Neurogenic Muscular Atrophy
Occipital Lobe
Positron-Emission Tomography
Longitudinal Studies
Cholinergic Synaptic Transmission
Brain
Donepezil
ACHE

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