PMID: 8591921Feb 1, 1987

Cholinergic drugs alter ciliary muscle response and receptor content

Investigative Ophthalmology & Visual Science
K Erickson-LamyD M Zlock

Abstract

Topical echothiophate administration to the cynomolgus monkey eye for 5-6.5 months produced marked subsensitivity of the accommodative response to pilocarpine and a 65% decrease in specific high affinity 3H-QNB binding sites (ostensibly indicating muscarinic receptors) in the ciliary muscle. The decrease in 3H-QNB binding sites was quantitatively similar in surgically untouched, totally iridectomized, and ciliary muscle disinserted eyes. Following a 5-month off treatment recovery period, 3H-QNB binding sites increased to more than twice the number in untreated control eyes. In echothiophate-treated eyes whose contralateral eyes had previously received atropine+echothiophate, 3H-QNB binding sites were three to six times more numerous than in other long-term echothiophate-treated eyes, and one to two times more numerous than in untreated controls. Topical pilocarpine administration for 1 day to 7 months reduced ciliary muscle 3H-QNB binding sites by approximately 25%. Alterations in muscarinic receptors during and following cholinergic drug therapy may in part explain the observed subsensitization and recovery of ciliary muscle physiological responses.

Related Concepts

Accommodation, Lens
Administration, Topical
Cholinesterase Inhibitors, Reversible
Ciliary Body
Phospholine Iodide
Macaca fascicularis
Smooth Muscle
Ophthalmic Solution
Salagen
Muscarinic Acetylcholine Receptor

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