Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study

Journal of Neural Transmission
Raffaele NardoneStefan Golaszewski

Abstract

Little is known about the neurochemical pathology of vascular dementia (VD); it was suggested that cholinergic mechanisms play a role in the pathogenesis of VD, as well as been established for Alzheimer's disease (AD). A recently devised test of motor cortex excitability, the short latency afferent inhibition (SAI), has been proven to depend upon the activity of cholinergic circuits in the human brain. To evaluate, in vivo, the functional role of the cholinergic system in the cognitive dysfunction associated with VD, we used this test in 20 patients with subcortical ischemic VD (SIVD) and in 25 control subjects. Mean SAI was significantly reduced in the SIVD patients; however, individual data varied widely, with SAI responses ranging from normal to markedly reduced values. These findings provide physiological evidence for an important role for cholinergic mechanisms in the pathogenesis of VD. The evaluation of SAI, similar to that described in AD patients, could help in identifying those patients who are more likely to respond to treatment with cholinergic drugs.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1991·Journal of Clinical and Experimental Neuropsychology·M F Mendez, M Ashla-Mendez
Nov 1, 1993·The Journal of Physiology·T KujiraiC D Marsden
Dec 1, 1993·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·O AlmkvistL O Wahlund
Jan 5, 1999·Brain : a Journal of Neurology·N R SeldenM M Mesulam
May 20, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·M F MendezK M Perryman
Mar 4, 2000·The Journal of Physiology·H TokimuraJ C Rothwell
May 16, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V KumarJ Veach
Sep 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Erkinjuntti
Nov 6, 2002·Journal of the Neurological Sciences·Rita MorettiAntonio Bava
Dec 13, 2002·Experimental Brain Research·Hartwig Roman Siebner, John Rothwell
Jul 10, 2003·Lancet Neurology·Gustavo C RománHelena C Chui
Aug 27, 2003·Neurology·D WilkinsonUNKNOWN Donepezil 308 Study Group
Sep 13, 2003·Stroke; a Journal of Cerebral Circulation·Sandra BlackUNKNOWN Donepezil 307 Vascular Dementia Study Group
Sep 1, 1959·The Journal of Nervous and Mental Disease·R M REITAN, E L TARSHES
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroJ C Rothwell
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·V Di LazzaroP A Tonali
Jan 12, 2005·Neurology·E PerryC Ballard
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·V Di LazzaroP Tonali
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Christian BoctiSandra E Black
Oct 7, 2006·Journal of Neural Transmission·R NardoneF Tezzon
Nov 24, 2006·Stroke; a Journal of Cerebral Circulation·Jessica S KeverneRaj N Kalaria
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Richard H SwartzSandra E Black

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Citations

Aug 9, 2011·Dementia and Geriatric Cognitive Disorders·Raffaele NardoneEugen Trinka
May 21, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mariagiovanna CantoneVincenzo Di Lazzaro
Mar 29, 2014·Journal of Neural Transmission·Raffaele NardoneFrancesco Brigo
Aug 17, 2010·Electromagnetic Biology and Medicine·Zheng-Yu FangXiao-Lin Huang
Feb 14, 2013·Brain Stimulation·Natallia LapitskayaSteven Laureys
Aug 31, 2011·Neuroscience Letters·Rita BellaGiovanni Pennisi
Aug 14, 2010·Archives of Gerontology and Geriatrics·Giovanni PennisiRita Bella
Jan 1, 2013·Neuroscience Letters·Rita BellaGiovanni Pennisi
Sep 30, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrea GuerraFlorinda Ferreri
Jun 13, 2012·Journal of Geriatric Psychiatry and Neurology·Sook Hui KimSeol-Heui Han
Apr 12, 2018·Brain Sciences·Claudia V TurcoAimee J Nelson
Apr 29, 2020·International Journal of Molecular Sciences·Luisa VinciguerraMariagiovanna Cantone
Nov 17, 2020·Neural Plasticity·Mariagiovanna CantoneGiovanni Di Pino
May 25, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudia V TurcoAimee J Nelson
Jul 3, 2021·Journal of Clinical Medicine·Jakub AntczakAgnieszka Słowik

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