PMID: 2501816Jan 1, 1989Paper

Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine

Psychopharmacology
E KristensenP Vestergaard

Abstract

Cholinergic functions were studied in ten non-depressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r = -0.83, P less than 10(-2] and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.

References

Feb 1, 1979·Scandinavian Journal of Dental Research·U BertramN E Larsen
May 1, 1979·British Journal of Clinical Pharmacology·A W PeckC Riddington
Jan 1, 1976·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H J Gundersen
Feb 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·J Mai, E Pedersen
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·A AutretS Roux
Mar 1, 1983·Journal of the Autonomic Nervous System·M Devor
Jan 1, 1981·European Journal of Clinical Pharmacology·E SzabadiC M Bradshaw
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·N SitaramS Gershon
Apr 1, 1983·Diabetologia·J D Mackay
Mar 1, 1983·Journal of the Autonomic Nervous System·R H Johnson
Feb 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·E Shur, S Checkley
Nov 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·E SzabadiC M Bradshaw
May 1, 1964·Journal of Applied Physiology·A ANGELONE, N A COULTER

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Citations

Apr 1, 1991·Psychiatry Research·V K YeraganiP Sherwood
Sep 5, 1995·Journal of the Autonomic Nervous System·V S Gavriysky
Oct 3, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·B T WalshE Bagiella
Jun 1, 1990·Acta Psychiatrica Scandinavica·V K YeraganiB Merlos
Feb 1, 1995·Journal of Clinical Psychopharmacology·J DingemanseJ H Jonkman
Mar 1, 2014·Journal of Pharmacy Practice·Gyula Bokor, Peter D Anderson
Jan 1, 1995·European Psychiatry : the Journal of the Association of European Psychiatrists·T RechlinW Kaschka

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