PMID: 2109302Feb 1, 1990Paper

Cholinergic effect on rat proximal convoluted tubule

Pflügers Archiv : European journal of physiology
T Wang, Y L Chan

Abstract

The effect of cholinergic agents on proximal tubular absorption of bicarbonate and fluid were examined to investigate the possible role of the cholinergic receptor in the regulation of renal function. Proximal convoluted tubule (PCT) and peritubular capillaries were perfused with bicarbonate-Ringer's solution containing radioactive inulin. Bicarbonate (total CO2) was determined by microcalorimetry. The rates of bicarbonate absorption (JHCO3) and fluid absorption (Jv) were 143.3 +/- 7.2 pEq/min.mm and 2.52 +/- 0.23 nl/min.mm, respectively. Addition of carbachol (10(-8) M) to the capillary perfusate reduced JHCO3 by 17% and Jv by 32%. A higher dose of carbachol (10(-6) M) did not further inhibit JHCO3 or Jv. Simultaneous perfusion of atropine (10(-5) M) together with carbachol (10(-8) M) abolished the inhibitory effect of carbachol on PCT transport. Atropine itself, however, had no effect on PCT transport. The inhibitory effect of carbachol was also diminished by lanthanum chloride (10(-4) M). Carbachol (10(-6) M) had no effects from the luminal side. W-7, a calmodulin antagonist, inhibited carbachol-induced effects. Ionophore A-23187 also inhibited Jv and JHCO3. However, there was no additive effect when A-23187 and carbachol we...Continue Reading

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Citations

Jan 4, 1993·European Journal of Pharmacology·W M BlankesteijnF G Russel
Aug 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhaopeng DuTong Wang
Sep 3, 2010·American Journal of Physiology. Renal Physiology·Sheldon WeinbaumAlan M Weinstein
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Mello-AiresM Oliveira-Souza
Nov 13, 2001·American Journal of Physiology. Renal Physiology·T WangG Giebisch
Apr 1, 1996·The American Journal of Physiology·H YamadaK Kurokawa

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