PMID: 9426377Jan 14, 1998Paper

Cholinergic enhancement by pyridostigmine increases the insulin response to glucose load in obese patients but not in normal subjects

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
G Del RioE Ghigo

Abstract

To further investigate the role, if any, of acetylcholine and the parasympathetic nervous system in modulating beta-cell secretion in man. Oral glucose load (OGTT, 100 g p.o. at 0 min) alone and preceded by pyridostigmine (PD, 120 mg p.o., 60 min before OGTT), a cholinesterase inhibitor, were administered on two different occasions, in random order, two or three days apart. Ten women with central obesity (OB, body mass index (BMI): 34.2 +/- 2.1 kg/m2, waist to hip ratio (WHR): 0.83 +/- 0.01, aged 39.0 +/- 5.3y) and six normal women (NS, BMI: 22.7 +/- 1.9 kg/m2, WHR: 0.74 +/- 0.01, aged 37.1 +/- 4.8y) were studied. Serum insulin, plasma glucose and plasma noradrenaline (NA) were measured at -60, -15 and 0 min, and then every 15 min up to +120 min. Insulin concentrations were measured in duplicate by immunoradiometric assay, glucose by glucose oxidase colorimetric method and NA was assayed after extraction with alumina using high performance liquid chromatography with electrochemical detection. Pulse rate (PR), systolic (SBP) and diastolic blood pressure (DBP) were also measured every 15 min during the tests by an automated cuff device. OGTT raised glucose concentrations in OB and NS (incremental area: 420 +/- 44 vs 288 +/- 70 mm...Continue Reading

Citations

Aug 8, 1998·European Journal of Pharmacology·E Simonsson, B Ahrén
Jan 12, 2005·Diabetes, Obesity & Metabolism·B Ahrén, G Pacini
Jul 11, 2006·The Journal of Clinical Investigation·Marc Prentki, Christopher J Nolan
Dec 19, 2006·European Journal of Pharmacology·Sabrina GrassiolliPaulo Cezar de Freitas Mathias
Dec 11, 2013·Medical Hypotheses·Milind WatveManawa Diwekar
Jan 1, 2013·Diabetes·Claire B BonalPedro L Herrera
Mar 5, 2003·Pharmacological Reviews·Máire E Doyle, Josephine M Egan
Dec 29, 2019·Diabetes·Rayner Rodriguez-DiazAlejandro Caicedo
Jul 17, 1999·The American Journal of Physiology·K L Teff, R R Townsend
Mar 10, 1999·The American Journal of Physiology·K L TeffR R Townsend

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