Aug 27, 2013

Cholinergic enhancement differentially modulates neural response to encoding during face identity and face location working memory tasks

Experimental Biology and Medicine
Giacomo HandjarasM L Furey


Potentiation of cholinergic transmission influences stimulus processing by enhancing signal detection through suppression and/or filtering out of irrelevant information (bottom-up modulation) and with top-down task-oriented executive mechanisms based on the recruitment of prefrontal and parietal attentional systems. The cholinergic system also plays a critical role in working memory (WM) processes and preferentially modulates WM encoding, likely through stimulus-processing mechanisms. Previous research reported increased brain responses in visual extrastriate cortical regions during cholinergic enhancement in the encoding phase of WM, independently addressing object and spatial encoding. The current study used functional magnetic resonance imaging to determine the effects of cholinergic enhancement on encoding of key visual processing features. Subjects participated in two scanning sessions, one during an intravenous (i.v.) infusion of saline and the other during an infusion of the acetylcholinesterase inhibitor physostigmine. In each scan session, subjects alternated between a face identity recognition and a spatial location WM. Enhanced cholinergic function increased neural activity in the ventral stream during encoding of fa...Continue Reading

Mentioned in this Paper

Cholinergic Effect
Neuro-Oncological Ventral Antigen 2
Immediate Recall
Acetylcholinesterase Inhibitors
Lingual - Oral Site Descriptor
Acute Cholinergic Dysautonomia
Visual Perception
Cholinesterase Inhibitors, Reversible

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