Cholinergic-Induced Specific Oscillations in the Medial Prefrontal Cortex to Reverse Propofol Anesthesia.

Frontiers in Neuroscience
Lieju WangMin Yan

Abstract

General anesthesia is a drug-induced reversible state comprised of altered states of consciousness, amnesia, analgesia, and immobility. The medial frontal cortex (mPFC) has been discovered to modulate the level of consciousness through cholinergic and glutamatergic pathways. The optogenetic tools combined with in vivo electrophysiological recording were used to study the neural oscillatory modulation mechanisms in mPFC underlying the loss of consciousness (LOC) and emergence. We found that optogenetic activation of both cholinergic and glutamatergic neurons in the basal forebrain (BF) reversed the hypnotic effect of propofol and accelerated the emergence from propofol-induced unconsciousness. The cholinergic light-activation during propofol anesthesia increased the power in the β (12-20 Hz) and low γ (20-30 Hz) bands. Conversely, glutamatergic activation increased the power at less specific broad (1-150 Hz) bands. The cholinergic-induced alteration to specific power bands after LOC had opposite effects to that of propofol. These results suggested that the cholinergic system might act on more specific cortical neural circuits related to propofol anesthesia.

References

Jul 5, 2005·Science·Donald Kennedy, Colin Norman
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan D BreshearsEric C Leuthardt
Apr 26, 2011·Annual Review of Neuroscience·Emery N BrownChrista J Van Dort
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laura D LewisPatrick L Purdon
Feb 5, 2013·Experimental Neurology·L Stan LeungTao Luo
Jan 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eran A MukamelPatrick L Purdon
Jan 25, 2014·Current Opinion in Neurobiology·Shinung Ching, Emery N Brown
Jul 30, 2014·Frontiers in Systems Neuroscience·Stefanie Blain-MoraesGeorge A Mashour
Oct 9, 2014·Anesthesiology·Stefanie Blain-MoraesGeorge A Mashour
Dec 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernard BloemFloris G Wouterlood
Oct 13, 2015·Nature Neuroscience·Min XuYang Dan
Feb 13, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Janneke C ZantRadhika Basheer
Jul 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Francisco J FloresPatrick L Purdon
Jun 26, 2018·Current Biology : CB·Dinesh PalGeorge A Mashour
Jan 18, 2019·Nature Communications·Marion BrickweddeHubert R Dinse
Nov 30, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dinesh PalGeorge A Mashour
Nov 17, 2020·Frontiers in Neuroscience·Tian-Yuan LuoShou-Yang Yu

❮ Previous
Next ❯

Software Mentioned

Graphpad Prism
Matlab
MATLAB chronux toolbox
Prism
Cerebus

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.