PMID: 9193139Jan 1, 1997Paper

Cholinergic innervation and receptors in the cerebellum

Progress in Brain Research
D JaarsmaJ Voogd

Abstract

We have studied the source and ultrastructural characteristics of ChAT-immunoreactive fibers in the cerebellum of the rat, and the distribution of muscarinic and nicotinic receptors in the cerebellum of the rat, rabbit, cat and monkey, in order to define which of the cerebellar afferents may use ACh as a neurotransmitter, what target structures are they, and which cholinergic receptor mediate the actions of these pathways. Our data confirm and extend previous observations that cholinergic markers occur at relatively low density in the cerebellum and show not only interspecies variability, but also heterogeneity between cerebellar lobules in the same species. As previously demonstrated by Barmack et al. (1992a,b), the predominant fiber system in the cerebellum that might use ACh as a transmitter or a co-transmitter is formed by mossy fibers originating in the vestibular nuclei and innervating the nodulus and ventral uvula. Our results show that these fibers innervate both granule cells and unipolar brush cells, and that the presumed cholinergic action of these fibers most likely is mediated by nicotinic receptors. In addition to cholinergic mossy fibers, the rat cerebellum is innervated by beaded ChAT-immunoreactive fibers. We h...Continue Reading

Citations

Jan 30, 2015·Frontiers in Cellular Neuroscience·Hassan MarzbanMojgan Rastegar
Mar 16, 2017·Frontiers in Neuroanatomy·Saad JwairTom J H Ruigrok
Nov 20, 2016·Frontiers in Synaptic Neuroscience·Eriola HoxhaMaria Concetta Miniaci
Apr 2, 2002·Neuroreport·Kanako TakatsukiYutaka Kirino
Sep 7, 2006·Journal of Neuroscience Research·Georgia A BishopJames S King
Mar 31, 2012·Brain Structure & Function·Ruth L StornettaPatrice G Guyenet
Feb 22, 2013·Journal of Neurophysiology·Eve R SchneiderSamuel S-H Wang
Sep 26, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Vasileios StolakisCharis Liapi
Jan 21, 2015·Nature Reviews. Neuroscience·Nadia L CerminaraRichard Apps
Nov 18, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J VígJ Hámori
Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jian-Guo LiDiana S Woodruff-Pak
Sep 4, 2015·Cerebellum & Ataxias·Maryam Rahimi-BalaeiHassan Marzban
Oct 10, 2015·The Cerebellum·Chris I De ZeeuwMarco Martina
Sep 2, 2016·Therapeutic Advances in Neurological Disorders·Hiroshi Mitoma, Mario Manto
Aug 18, 2018·Neurochemical Research·J PickfordZ I Bashir
Dec 22, 2006·The Journal of Comparative Neurology·Joost L M JongenJan C Holstege
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
Nov 6, 2013·BioMed Research International·Sarah E Van DineRaddy L Ramos
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Joshua J White, Roy V Sillitoe
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Craig F FerrisC Sue Carter
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Regina P MarkusLivia A C Reno
May 18, 2007·Annual Review of Cell and Developmental Biology·Roy V Sillitoe, Alexandra L Joyner
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Salim Al-Rejaie, M Saeed Dar
Aug 26, 2016·Reviews in the Neurosciences·Changzheng ZhangTifei Yuan
Dec 15, 2017·The Journal of Comparative Neurology·Vincenzo BenagianoGlauco Ambrosi
Mar 8, 2013·PloS One·Gert Van DijckTahl Holtzman

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