Cholinergic manipulations bidirectionally regulate object memory destabilization

Learning & Memory
Mikaela L StiverBoyer D Winters

Abstract

Consolidated memories can become destabilized and open to modification upon retrieval. Destabilization is most reliably prompted when novel information is present during memory reactivation. We hypothesized that the neurotransmitter acetylcholine (ACh) plays an important role in novelty-induced memory destabilization because of its established involvement in new learning. Accordingly, we investigated the effects of cholinergic manipulations in rats using an object recognition paradigm that requires reactivation novelty to destabilize object memories. The muscarinic receptor antagonist scopolamine, systemically or infused directly into the perirhinal cortex, blocked this novelty-induced memory destabilization. Conversely, systemic oxotremorine or carbachol, muscarinic receptor agonists, administered systemically or intraperirhinally, respectively, mimicked the destabilizing effect of novel information during reactivation. These bidirectional effects suggest a crucial influence of ACh on memory destabilization and the updating functions of reconsolidation. This is a hitherto unappreciated mnemonic role for ACh with implications for its potential involvement in cognitive flexibility and the dynamic process of long-term memory stor...Continue Reading

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Citations

Dec 11, 2019·The European Journal of Neuroscience·Yann S Mineur, Marina R Picciotto
Mar 13, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Satoshi Kida
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Feb 24, 2018·Neurobiology of Learning and Memory·J Jane ZhangKarim Nader
Nov 6, 2018·Neurobiology of Learning and Memory·Cassidy E WidemanBoyer D Winters

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