Cholinergic mechanism and blood pressure regulation in the central nervous system

Brain Research Bulletin
T Kubo

Abstract

Cholinergic neurons in numerous brain regions have been implicated in blood pressure regulation. One of the most important brain regions where cholinergic neurons play a role in the pathogenesis of hypertension is the rostral ventrolateral medulla (RVL), an essential source of efferent sympathetic activity. Pharmacological and biochemical studies have revealed that acetylcholine release in the RVL is increased in experimental hypertension regardless of its etiology and that this enhanced release of acetylcholine leads to hypertension. The lateral parabrachial nucleus, another important hindbrain area involved in blood pressure regulation, is responsible for the enhanced release of acetylcholine in the RVL of hypertensive animals. Moreover, recent studies have demonstrated the involvement of the hypothalamic defence area, an area believed to be involved in the hypertension induced by chronic stress, in the release of acetylcholine in the RVL and also have demonstrated the existence of direct projections from the hypothalamic structures to the lateral parabrachial nucleus. More studies about mechanisms of the enhanced release of acetylcholine in the RVL of experimentally hypertensive animals will provide important information for...Continue Reading

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Citations

May 17, 2001·Current Hypertension Reports·J M Wyss, S H Carlson
Sep 12, 2000·Current Hypertension Reports·J M Wyss, S H Carlson
Jul 3, 2013·Neuroscience Letters·Mohammad Naser ShafeiMahdi Hasanzade Daloee
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Dec 4, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Yesim Ozarda IlcolIsmail H Ulus
Jan 27, 2016·Neuroscience·Charles J VierckRonald G Wiley
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Nov 3, 2011·Journal of Receptor and Signal Transduction Research·Hidetoshi AsaiOsamu Doi
Feb 26, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yu-Wen E DaiLing-Ling Hwang
Jun 26, 2012·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Sep 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takao Kubo
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Arto J HautalaMikko P Tulppo
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine DeprezStefan Sunaert
Apr 14, 2017·Pflügers Archiv : European journal of physiology·Yuta OkamuraHideyuki Yamawaki
Nov 1, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S F FonsecaA C R Lacerda

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