Cholinergic mechanisms involved in cortical activation during arousal

Electroencephalography and Clinical Neurophysiology
J Y Montplaisir

Abstract

Spontaneous and evoked cortical electrical activity of the post-central gyrus was studied in 5 unparalyzed, unanesthetized monkeys during slow-wave sleep (SWS) and wakefulness (W), before and after the administration of a muscarinic anticholinergic agents, hyoscine. It was found that hyoscine reproduces the effect of SWS: (1) on spontaneous EEG activity and single unit discharges of the somatosensory cortes without any concomitant behavioral sleep; and (2) on surface evoked potentials and reactivity of cortical neurons to peripheral electrical stimulation. Short episodes of EEG desynchronization were noted in the alert state after hyoscine suggesting the existence of a phasic activating system unblocked by hyoscine. These observations support the concept of an EEG-behavior dissociation produced by muscarinic anticholinergic agents and extend this concept to single neuron activity. These observations also lead to the conclusion that tonic EEG activation during arousal may be cholinergic at the cortical level even though other neurotransmitters may be involved.

References

Oct 16, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·S E RobinsonE Costa
Apr 7, 1977·European Journal of Pharmacology·N SitaramJ C Gillin
Feb 1, 1996·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C L LimC Yiannikas
Sep 7, 2012·Epilepsy Research and Treatment·Péter HalászAnna Szűcs
Oct 27, 2012·Neurologic Clinics·Alex Moszczynski, Brian James Murray
Aug 1, 1980·Experimental Neurology·K C Marshall, J S Murray
Mar 5, 2004·Journal of Sleep Research·Péter HalászRóbert Bódizs
Feb 16, 2017·Frontiers in Behavioral Neuroscience·Ines VillanoGiovanni Messina

Citations

Dec 1, 1970·Electroencephalography and Clinical Neurophysiology·D R Humphrey
Sep 1, 1973·Electroencephalography and Clinical Neurophysiology·J Y Montplaisir, E Sazie
Jun 1, 1968·Electroencephalography and Clinical Neurophysiology·D F LindsleyK F Killam
Sep 1, 1969·Electroencephalography and Clinical Neurophysiology·Y Lamarre
May 1, 1969·Journal of Neurochemistry·J SchuberthA Sundwall
Oct 1, 1969·Canadian Journal of Physiology and Pharmacology·H H Jasper, I Koyama
Jan 1, 1967·The Journal of Physiology·B Collier, J F Mitchell
Jul 28, 1954·The Journal of Physiology·J CROSSLAND, A J MERRICK
Oct 1, 1962·British Journal of Pharmacology and Chemotherapy·N J GIARMAN, G PEPEU
Mar 1, 1964·Experimental Neurology·M RANDICD W STRAUGHAN
Sep 4, 1964·Science·G PEPEU, P MANTEGAZZINI
Apr 1, 1955·A.M.A. Archives of Neurology and Psychiatry·F RINALDI, H E HIMWICH
Sep 2, 1959·The Journal of Physiology·D H HUBEL
May 1, 1951·Electroencephalography and Clinical Neurophysiology·W H FUNDERBURK, T J CASE
Feb 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·A Wikler
Jan 1, 1963·The Journal of Physiology·J F Mitchell
Jan 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·J M TOBIASA A LEPINAT

Related Concepts

Vigilance, Cortical
Microelectrodes
Slow Virus Diseases
Sleep, Slow-Wave
Isopto Hyoscine
Neurons
Electrical Activity of Brain
Cercopithecidae
Platyrrhini
Scopolamine

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.