Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus

Journal of Neurophysiology
Feng Luo, Zelma H T Kiss

Abstract

Chronic, high-frequency (>100 Hz) electrical stimulation, known as deep brain stimulation (DBS), of the internal segment of the globus pallidus (GPi) is a highly effective therapy for Parkinson's disease (PD) and dystonia. Despite some understanding of how it works acutely in PD models, there remain questions about its mechanisms of action. Several hypotheses have been proposed, such as depolarization blockade, activation of inhibitory synapses, depletion of neurotransmitters, and/or disruption/alteration of network oscillations. In this study we investigated the cellular mechanisms of high-frequency stimulation (HFS) in entopeduncular nucleus (EP; rat equivalent of GPi) neurons using whole cell patch-clamp recordings. We found that HFS applied inside the EP nucleus induced a prolonged afterdepolarization that was dependent on stimulation frequency, pulse duration, and current amplitude. The high frequencies (>100 Hz) and pulse widths (>0.15 ms) used clinically for dystonia DBS could reliably induce these afterdepolarizations, which persisted under blockade of ionotropic glutamate (kynurenic acid, 2 mM), GABAA (picrotoxin, 50 μM), GABAB (CGP 55845, 1 μM), and acetylcholine nicotinic receptors (DHβE, 2 μM). However, this effect ...Continue Reading

References

Jan 1, 1991·Progress in Neurobiology·E Garcia-Rill
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D M WeinerM R Brann
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D RileyB Reid
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·L D PossaniJ Z Juliá
Apr 19, 2000·Neurological Research·E B Montgomery, K B Baker
Jun 6, 2000·The Journal of Biological Chemistry·M SchaeferG Schultz
Jul 19, 2000·Journal of Neurophysiology·J O DostrovskyA M Lozano
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jerrold L Vitek
Oct 5, 2002·Journal of Neurophysiology·Cameron C McIntyre, Warren M Grill
Nov 15, 2002·Nature·Alexei V EgorovAngel A Alonso
Jan 23, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Stig RehncronaOlof Sydow
Apr 21, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Joachim K KraussTipu Z Aziz
Jun 26, 2004·The Journal of Physiology·Trent AndersonZelma H T Kiss
Sep 9, 2004·Journal of Neurosurgery·Kendall H LeeUhnoh Kim
Feb 4, 2005·The New England Journal of Medicine·Marie VidailhetUNKNOWN French Stimulation du Pallidum Interne dans la Dystonie (SPIDY) Study Group
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trent R AndersonZelma H T Kiss
Mar 24, 2006·Journal of Neurophysiology·Karl J IremongerZelma H T Kiss
Aug 25, 2006·The New England Journal of Medicine·Daniel Tarsy, David K Simon
Jan 26, 2007·Brain : a Journal of Neurology·Alessandro StefaniPaolo Mazzone
Jul 20, 2007·Nature Reviews. Neuroscience·Morten L KringelbachTipu Z Aziz
Oct 2, 2007·Trends in Neurosciences·Antonio PisaniD James Surmeier
Oct 2, 2007·Brain : a Journal of Neurology·Zelma H T KissUNKNOWN Canadian Movement Disorders Group
Dec 18, 2007·Pharmacology & Therapeutics·Christopher J LangmeadCharlie Reavill
Sep 24, 2009·Brain : a Journal of Neurology·M U FerrayeP Pollak
Jun 4, 2010·The New England Journal of Medicine·Kenneth A FollettUNKNOWN CSP 468 Study Group
Aug 6, 2010·Annals of Neurology·Adrian W LaxtonAndres M Lozano
Feb 12, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·René ReeseJoachim K Krauss
Jun 8, 2011·The European Journal of Neuroscience·Jamilur Rahman, Thomas Berger
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scellig S D StonePaul W Frankland
Jan 10, 2012·Handbook of Experimental Pharmacology·Joshua A GoldbergD James Surmeier
May 23, 2012·Current Opinion in Neurology·Alberto Albanese, Stefania Lalli

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Citations

Aug 28, 2020·The European Journal of Neuroscience·Alessandro StefaniSalvatore Galati
Mar 28, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Feng Luo, Zelma Ht Kiss

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