Cholinergic modulation of an opposed effect of d-amphetamine and methylphenidate on the rearing response.

Psychopharmacologia
K S Bryan, G Ellison

Abstract

Rats given d-amphetamine (1 mg/kg) engage in frequent, short-duration rearing responses, whereas rats given methylphenidate (1 mg/kg) make less frequent, long-duration responses. The effects on this behavior of mixing d-amphetamine or methylphenidate with scopolamine or physostigmine suggest that this opposed action on rearing response duration is related to cholinergic-catecholaminergic balance. The anticholinergic agent scopolamine produces changes in rearing response duration similar to those produced by d-amphetamine, while the cholinergic agent physostigmine lengthens response duration and further potentiates this effect of methylphenidate.

References

Aug 1, 1972·Archives of General Psychiatry·S H Snyder
Nov 11, 1968·JAMA : the Journal of the American Medical Association·J G Millichap
Jan 1, 1972·Psychopharmacologia·D M Warburton, K Brown
Jan 1, 1972·Psychopharmacologia·D S JanowksyH J Sekerke
Jun 1, 1969·The Journal of Nervous and Mental Disease·R M Knights, G G Hinton
Mar 12, 1971·Nature·D M Warburton, K Brown
Feb 1, 1968·Animal Behaviour·M Zucker, W E Howard
Jan 1, 1966·Psychopharmacologia·J M Whitehouse
Jan 1, 1958·A.M.A. Archives of Neurology and Psychiatry·E CALLAWAY, R I BAND
Jan 1, 1963·Psychological Review·P L CARLTON

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Citations

Jan 1, 1980·Psychopharmacology·D E MossR L Johnson

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