Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

Frontiers in Cellular Neuroscience
Rashmi GamageErika Gyengesi

Abstract

Aging is a complex biological process that increases the risk of age-related cognitive degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body Dementia (LBD), and mild cognitive impairment (MCI). Even non-pathological aging of the brain can involve chronic oxidative and inflammatory stress, which disrupts the communication and balance between the brain and the immune system. There has been an increasingly strong connection found between chronic neuroinflammation and impaired memory, especially in AD. While microglia and astrocytes, the resident immune cells of the central nervous system (CNS), exerting beneficial effects during the acute inflammatory phase, during chronic neuroinflammation they can become more detrimental. Central cholinergic circuits are involved in maintaining normal cognitive function and regulating signaling within the entire cerebral cortex. While neuronal-glial cholinergic signaling is anti-inflammatory and anti-oxidative, central cholinergic neuronal degeneration is implicated in impaired learning, memory sleep regulation, and attention. Although there is evidence of cholinergic involvement in memory, fewer studies have linked the cholinergic anti-inflammatory and anti-oxida...Continue Reading

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elisa NavarroManuela G López
Jun 3, 2021·Biomedicines·Isaac G OnyangoGorazd B Stokin
May 25, 2021·Frontiers in Aging Neuroscience·Weiqi BaoYiyun Henry Huang
Jun 3, 2021·International Journal of Molecular Sciences·Roberta PiovesanaAda Maria Tata
Jun 20, 2021·Bioorganic & Medicinal Chemistry Letters·Murilo K A YonekawaEdson Dos A Dos Santos
Jul 30, 2021·Frontiers in Aging Neuroscience·Jose L MartinezAnita Bhattacharyya
Jul 18, 2021·Journal of Neurochemistry·Changiz GeulaMarek-Marsel Mesulam

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Methods Mentioned

BETA
electron microscopy
nuclear translocation
transgenic

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