Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. I. Central nervous system

Neuroscience
M K SchäferE Weihe

Abstract

Antibodies directed against the C-terminus of the rat vesicular acetylcholine transporter mark expression of this specifically cholinergic protein in perinuclear regions of the soma and on secretory vesicles concentrated within cholinergic nerve terminals. In the central nervous system, the vesicular acetylcholine transporter terminal fields of the major putative cholinergic pathways in cortex, hippocampus, thalamus, amygdala, olfactory cortex and interpeduncular nucleus were examined and characterized. The existence of an intrinsic cholinergic innervation of cerebral cortex was confirmed by both in situ hybridization histochemistry and immunohistochemistry for the rat vesicular acetylcholine transporter and choline acetyltransferase. Cholinergic interneurons of the olfactory tubercle and Islands of Calleja, and the major intrinsic cholinergic innervation of striatum were fully characterized at the light microscopic level with vesicular acetylcholine transporter immunohistochemistry. Cholinergic staining was much more extensive for the vesicular acetylcholine transporter than for choline acetyltransferase in all these regions, due to visualization of cholinergic nerve terminals not easily seen with immunohistochemistry for chol...Continue Reading

References

Jan 1, 1975·Journal of Neurochemistry·M BrownsteinJ M Saavedra
May 22, 1992·Annals of the New York Academy of Sciences·N H BarmackF P Eckenstein
Apr 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·E Weihe
Mar 1, 1991·Brain, Behavior, and Immunity·H J Zentel, E Weihe
Dec 1, 1991·The Journal of Comparative Neurology·Z Henderson, F E Sherriff
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C F IbáñezH Persson
Jan 1, 1990·Ciba Foundation Symposium·K FuxeP Eneroth
Feb 1, 1990·The Journal of Comparative Neurology·D A RuggieroD J Reis
Jun 1, 1986·The Journal of Comparative Neurology·T Voigt
Mar 1, 1987·Experimental Eye Research·J B Hutchins, J G Hollyfield
Jul 1, 1987·Experimental Eye Research·J B Hutchins
Jan 1, 1987·Annals of the New York Academy of Sciences·L Edvinsson
Jan 30, 1986·Neuroscience Letters·E Gould, L L Butcher
Feb 28, 1985·Neuroscience Letters·B H WainerE J Mufson
Mar 6, 1995·The Journal of Comparative Neurology·M SchemannM Mäder
May 1, 1995·Trends in Neurosciences·T B UsdinJ D Erickson

❮ Previous
Next ❯

Citations

Nov 7, 2000·The Journal of Comparative Neurology·N MechawarL Descarries
Nov 19, 2002·Journal of Neurobiology·Young-Hwan JoLorna W Role
Mar 3, 1998·Journal of Molecular Neuroscience : MN·S H HahmL E Eiden
Jan 28, 2005·Journal of the Association for Research in Otolaryngology : JARO·Barbara J MorleyJorge Rodriguez-Sierra
May 12, 2005·Brain Research. Developmental Brain Research·Brygida BerseJan Krzysztof Blusztajn
Oct 7, 2000·Autonomic Neuroscience : Basic & Clinical·G Guidry, S C Landis
Aug 15, 2002·Neurochemistry International·Marco A M PradoFernando G de Mello
Oct 21, 1998·Neuroscience Letters·J Schenda, L Vollrath
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Patrick O J Covernton, Robin A J Lester
Oct 28, 1998·Journal of Physiology, Paris·G Pepeu, P Blandina
Oct 28, 1998·Journal of Physiology, Paris·E WeiheL E Eiden
Jan 23, 1999·Current Opinion in Neurobiology·J P LundG Scott
Jun 6, 2009·Acta Pharmacologica Sinica·Xuesi M Shao, Jack L Feldman
Aug 24, 1999·The European Journal of Neuroscience·M ZaninettiM Raggenbass
Dec 3, 2011·Nucleosides, Nucleotides & Nucleic Acids·Johannes GerlachMartin K-H Schäfer
Mar 2, 1999·Journal of Computer Assisted Tomography·H D GageJ C Eisenach
Jun 11, 2011·Science·Yann S MineurMarina R Picciotto
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li JiangLorna W Role
May 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takato HiranitaTsuneyuki Yamamoto
Dec 9, 1998·FEBS Letters·W J SchwaebleM K Schäfer
Jul 29, 2016·Neurogenesis·Brent AsricanChay T Kuo
Jun 12, 2013·The Journal of Comparative Neurology·Laurent GautronJoel K Elmquist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.