Cholinergic Pathway SNPs and Postural Control in 477 Older Adults

Frontiers in Aging Neuroscience
Carina ArnoldWalter Maetzler

Abstract

Objective: To determine whether single nucleotide polymorphisms (SNPs) of the cholinergic system and quantitative parameters of postural control are associated in healthy older adults. This is a cross-sectional analysis from the TREND study. Methods: All participants performed a static postural control task for 30 s on a foam pad in semitandem stance and eyes closed. We analyzed mean power frequency (MPF), area, acceleration, jerk, and velocity from a mobile sensor worn at the lower back using a validated algorithm. Genotypes of four SNPs in genes involved in the cholinergic system (SLC5A7, CHAT, BCHE, CHRNA4) were extracted from the NeuroX chip. All participants present a normal neurological examination and a Minimental state examination score >24. Results: Four hundred and seventy seven participants were included. Mean age was 69 years, 41% were female. One SNP of the cholinergic pathway was significantly associated with a quantitative postural control parameter. The minor allele of rs6542746 in SLC5A7 was associated with lower MPF (4.04 vs. 4.22 Hz; p = 3.91 × 10-4). Moreover, the following associations showed trends toward significance: minor allele of rs6542746 in SLC5A7 with higher anteroposterior acceleration (318 vs. 28...Continue Reading

References

Nov 5, 1997·The New England Journal of Medicine·M E Tinetti, C S Williams
Sep 30, 1999·Gait & Posture·C F RungeF E Zajac
May 19, 2000·Yonsei Medical Journal·M S LeeC D Marsden
Aug 22, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M H Woollacott
Aug 26, 2000·Brain : a Journal of Neurology·P A Pahapill, A M Lozano
May 2, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Allan L AdkinMandar S Jog
Feb 24, 2004·Medical & Biological Engineering & Computing·L RocchiA Cappello
May 16, 2006·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Susan DewhurstGiuseppe De Vito
Apr 24, 2007·Neuropsychologia·Rick C HelmichIvan Toni
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sofie HeuninckxStephan P Swinnen
Jun 10, 2008·Lancet Neurology·Daniel G HealyUNKNOWN International LRRK2 Consortium
Oct 31, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anna FrenklachHelen Bronte-Stewart
Jan 1, 2008·Clinical Interventions in Aging·Patrick ManckoundiaPierre Pfitzenmeyer
Apr 23, 2009·The Journal of Biological Chemistry·Erez PodolyHermona Soreq
May 12, 2009·Neuroscience Letters·Ivar ReinvangThomas Espeseth
Sep 15, 2009·Gait & Posture·Molly A McVeyJonathan D Mahnken
Nov 7, 2009·Journal of Motor Behavior·Neville Hogan, Dagmar Sternad
Mar 25, 2010·Journal of the International Neuropsychological Society : JINS·Ivar ReinvangThomas Espeseth
Jul 16, 2010·The Journal of Clinical Investigation·Carine KarachiChantal François
Aug 11, 2010·Clinical Biomechanics·Itshak MelzerLars I E Oddsson
Feb 26, 2011·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Luca PalmeriniLorenzo Chiari
Jun 7, 2011·Parkinsonism & Related Disorders·Martina ManciniLorenzo Chiari
Sep 8, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Alison YarnallDavid J Burn
Oct 20, 2011·Genes, Brain, and Behavior·S-J TsaiJ-P Hwang
Mar 1, 2012·Neuroscience and Biobehavioral Reviews·P M GreenwoodThomas Espeseth
Mar 30, 2012·PloS One·Walter MaetzlerLorenzo Chiari
Aug 24, 2012·Journal of Neuroengineering and Rehabilitation·Martina ManciniFay B Horak
Sep 11, 2012·Brain : a Journal of Neurology·Lynn RochesterDavid J Burn
Jul 31, 2013·Gait & Posture·Thibault DeschampsJean-Baptiste Mignardot
Sep 14, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Walter MaetzlerBastiaan R Bloem
Sep 24, 2013·Brain : a Journal of Neurology·Martijn L T M MüllerNicolaas I Bohnen
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Fay B Horak, Martina Mancini
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Walter MaetzlerBastiaan R Bloem

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