Cholinergic receptor activation by pyridostigmine restores growth hormone (GH) responsiveness to GH-releasing hormone administration in obese subjects: evidence for hypothalamic somatostatinergic participation in the blunted GH release of obesity

The Journal of Clinical Endocrinology and Metabolism
F CordidoC Dieguez

Abstract

GH secretion in response to provocative stimuli is decreased in obese individuals. However, the precise mechanism causing this decrease is unknown. In an attempt to determine if reduced cholinergic stimulation accounts for the decreased GH secretion, we studied the effect of enhanced cholinergic tone induced by pyridostigmine on GHRH-stimulated GH secretion in a group of seven obese and seven normal subjects. When GHRH (100 micrograms, iv) was administered after placebo in the obese group, mean plasma GH rose from 0.5 +/- (0.1 (+/- SE) to 3.6 +/- 1.5 micrograms/L at 30 min. When the same obese subjects were given GHRH 60 min after pyridostigmine administration (120 mg, orally), the mean plasma GH level rose from 1.8 +/- 0.6 to 21.0 +/- 7.5 micrograms/L at 30 min. The responses to placebo and pyridostigmine were significantly different at 15, 30, 45, 60, and 90 min. In the normal subjects, a similar dose of GHRH induced a GH peak of 24.3 +/- 7.1 micrograms/L, and the GHRH-stimulated peak was significantly higher (56.2 +/- 16.8 micrograms/L) after pyridostigmine administration. To study the effect of pyridostigmine alone six other obese and six other normal subjects were tested with pyridostigmine or placebo on different days. In...Continue Reading

Citations

Jan 1, 1993·Psychoneuroendocrinology·J M Gómez-SáezJ Soler
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J PopovaS Zaharieva
Mar 1, 1995·Trends in Endocrinology and Metabolism : TEM·C Dieguez, F F Casanueva
Jan 9, 2004·Endocrinology and Metabolism Clinics of North America·Panagiotis Kokkoris, F Xavier Pi-Sunyer
Dec 1, 1991·Clinical Endocrinology·C MuruaisC Diéguez
Nov 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·L BeccariaG Chiumello
Apr 27, 2010·Journal of Endocrinological Investigation·F LanfrancoM Maccario
Apr 9, 2005·European Journal of Endocrinology·Sander V HaijmaHans P F Koppeschaar
Nov 10, 2005·Journal of Endocrinological Investigation·M GolaA Giustina
May 18, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M AndersenT L Nielsen
Aug 10, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Paula Álvarez-CastroFernando Cordido
Mar 20, 1999·Baillière's Clinical Endocrinology and Metabolism·F F Casanueva, C Dieguez
Jul 27, 2004·Clinical Endocrinology·Paula Alvarez-CastroFernando Cordido
Feb 1, 1997·Metabolism: Clinical and Experimental·T J Lauterio, F M Perez
Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·M E Geffner
Apr 23, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Marianne Andersen
Aug 4, 2005·The Journal of Clinical Endocrinology and Metabolism·Dorte GlintborgMarianne Andersen
Jun 11, 2019·Endocrine Reviews·Richard I G Holt, Ken K Y Ho
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·P RietschelS Grinspoon
Dec 29, 1995·Annals of the New York Academy of Sciences·P M Peeke, G P Chrousos
Aug 22, 2006·Diabetes, Obesity & Metabolism·P Alvarez-CastroF Cordido
Jun 1, 1992·Journal of Endocrinological Investigation·S LocheC Pintor
Aug 5, 1998·The American Journal of Physiology·T J LauterioR Ramirez

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