PMID: 22574675May 12, 2012Paper

Cholinergic receptor system as a target for treating alcohol abuse and dependence

Recent Patents on CNS Drug Discovery
Shafiqur Rahman, Mark A Prendergast

Abstract

Alcohol dependence and other alcohol use disorders are major public health problems. Due to the limitations in efficacy with current medications for the management of alcohol abuse and dependence, there is a need for alterantive pharmacotherapies. Emerging preclinical and clinical data indicate that brain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of ion channels expressed in the mammalian brain, are critical targets for the development of pharmacotherapies for alcohol abuse and dependence. Evidence suggests that the effects of nAChR partial agonists and antagonists have promise for the management of alcohol dependence and other alcohol use disorders. The present review summarizes information on the most recent pharmacotherapies targeting nAChRs, including cytisine, sazetidine A, varenicline, lobeline mecamylamine, PF-4575180 and CP-601932, that are able to treat alcohol dependence. The role of α4β2*, α3β4* and/or other subtypes associated effects in reducing voluntary alcohol consumption or modulate alcohol drinking behavior in animal models and humans are reviewed. Patents discussed include those targeting α4β2* and α7 subtypes as well as cholinesterase inhibitors. Future research indicating the abilit...Continue Reading

Citations

Mar 31, 2012·Addiction Biology·Raye Z LittenAntonio Noronha
Apr 15, 2014·Life Sciences·Liana Dantas da Costa E SilvaJaqueline Nascimento Picada
Jul 3, 2015·Brain Sciences·Joan Y Holgate, Selena E Bartlett
Sep 4, 2015·Alcoholism, Clinical and Experimental Research·Kelle M FranklinWilliam J McBride
Nov 20, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·C E Van SkikeK Nixon
Dec 4, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monzurul Amin Roni, Shafiqur Rahman
Jul 23, 2013·Pharmacology, Biochemistry, and Behavior·Ravi K Sajja, Shafiqur Rahman
Jan 7, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Robert L GannonMark J Millan
Feb 3, 2015·Frontiers in Neuroscience·Shafiqur RahmanRichard L Bell
Mar 6, 2021·Neuroscience and Biobehavioral Reviews·Nicolaj MistarzAngelina Isabella Mellentin

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