Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets

American Journal of Physiology. Endocrinology and Metabolism
Nicolai M DolibaFranz M Matschinsky

Abstract

Neural and endocrine factors (i.e., Ach and GLP-1) restore defective glucose-stimulated insulin release in pancreatic islets lacking sulfonylurea type 1 receptors (SUR1(-/-)) (Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, and Matschinsky FM. Am J Physiol Endocrinol Metab 286: E834-E843, 2004). The goal of the present study was to assess fuel-induced respiration in SUR1(-/-) islets and to correlate it with changes in intracellular Ca(2+), insulin, and glucagon secretion. By use of a method based on O(2) quenching of phosphorescence, the O(2) consumption rate (OCR) of isolated islets was measured online in a perifusion system. Basal insulin release (IR) was 7-10 times higher in SUR1(-/-) compared with control (CON) islets, but the OCR was comparable. The effect of high glucose (16.7 mM) on IR and OCR was markedly reduced in SUR1(-/-) islets compared with CON. Ach (0.5 microM) in the presence of 16.7 mM glucose caused a large burst of IR in CON and SUR1(-/-) islets with minor changes in OCR in both groups of islets. In SUR1(-/-) islets, high glucose failed to inhibit glucagon secretion during stimulation with amino acids or Ach. We conclude that 1) reduced glucose respons...Continue Reading

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Jan 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Nicolai M DolibaFranz M Matschinsky
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Citations

Sep 7, 2012·Diabetes, Obesity & Metabolism·Nicolai M DolibaFranz M Matschinsky
Jul 8, 2010·American Journal of Physiology. Endocrinology and Metabolism·Nicolai M DolibaFranz M Matschinsky
Sep 29, 2011·American Journal of Physiology. Endocrinology and Metabolism·Nicolai M DolibaFranz M Matschinsky
Jul 9, 2009·American Journal of Physiology. Endocrinology and Metabolism·Seung-Ryoung JungIan R Sweet
Apr 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Krishna M BoiniFlorian Lang
Oct 7, 2009·The Journal of Clinical Investigation·Belinda GierGisela Drews
Jun 11, 2010·Molecular Endocrinology·Nan GaoKlaus H Kaestner
Jun 15, 2011·Physiology & Behavior·Karen L Teff, Sangwon F Kim
Nov 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I R SweetK Ferreri
Oct 3, 2007·Cell Metabolism·Nan GaoKlaus H Kaestner
Feb 7, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Robert L SorensonFranz M Matschinsky
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Nicolai M DolibaFranz M Matschinsky
Jan 31, 2007·Endocrine Reviews·Jesper GromadaClaes B Wollheim

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