PMID: 3766721Oct 1, 1986Paper

Cholinergic regulation of Na absorption by turtle colon: role of basolateral K conductance

The American Journal of Physiology
C J Venglarik, D C Dawson

Abstract

The mechanism underlying the muscarinic inhibition of colonic Na absorption is unknown. In this study the effects of carbachol on active Na transport and basolateral K conductance were compared in the isolated turtle colon. Carbachol produced a biphasic response in both Na transport and basolateral K conductance. The response consisted of a transient activation followed by a sustained inhibition and was blocked by atropine. Submucosal cholinergic neurons were implicated in the regulation of colonic transport by employing depolarizing agents to release endogenous acetylcholine. Depolarizing agents produced a carbachol-like response that was atropine-sensitive. Finally, experiments with the Ca ionophores, A23187 and ionomycin, suggested that the muscarinic response may be mediated, at least in part, by changes in cellular Ca. These experiments provide evidence that cholinergic neurons are present in the turtle colon submucosa, muscarinic agonists cause a change in basolateral K conductance that may be an important event in the regulation of colonic Na absorption, and a Ca second messenger system may be involved in mediating the response.

References

Apr 4, 1979·Biochimica Et Biophysica Acta·W Nagel
Nov 1, 1977·The Journal of Physiology·J G BrowningP A Sanford
Aug 1, 1978·The Journal of Physiology·J G BrowningJ S Redfern
Sep 25, 1978·The Journal of Membrane Biology·S M Thompson, D C Dawson
Mar 1, 1985·Pflügers Archiv : European journal of physiology·D R Halm, D C Dawson
Apr 1, 1968·European Journal of Pharmacology·Y Ogura, Y Mori
Apr 1, 1984·Pflügers Archiv : European journal of physiology·M Soejima, A Noma
Jun 1, 1984·The Biochemical Journal·M J Berridge
Sep 1, 1983·The Journal of General Physiology·K L Kirk, D C Dawson
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A Trautmann, A Marty
Feb 9, 1981·Brain Research·A ConstantiD A Brown

❮ Previous
Next ❯

Citations

Jan 1, 1990·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Brummermann, E Simon
May 15, 2007·The New England Journal of Medicine·Horacio J Adrogué, Nicolaos E Madias
Oct 1, 1988·American Journal of Health Promotion : AJHP·L K Trent, T L Conway
Feb 1, 1989·Digestive Diseases and Sciences·A KuwaharaB McGregor
Jul 1, 1990·Pflügers Archiv : European journal of physiology·J MarchettiF Morel
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B SemmekrotJ Willems
Apr 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·V M Buckalew
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hisayoshi HayashiYuichi Suzuki
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L GaoH J Forman
May 14, 2008·American Journal of Respiratory Cell and Molecular Biology·Jennifer S GuimbellotJeong S Hong
Mar 31, 2016·Journal of Hypertension·Vito M Campese
Aug 8, 2018·Clinical Medicine Insights. Endocrinology and Diabetes·Constantine E KosmasEliscer Guzman
May 12, 2000·British Journal of Pharmacology·S K InglisS M Wilson
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Matthew A BaileyJohn J Mullins
Mar 13, 2009·Current Hypertension Reports·Stefan ReuterUta Hillebrand
Oct 11, 2012·European Journal of Clinical Nutrition·M Y EndoY Fukuba
Oct 1, 1991·Pflügers Archiv : European journal of physiology·C Van Renterghem, M Lazdunski
Oct 22, 1987·The New England Journal of Medicine·T W KurtzR C Morris
Jan 1, 1986·Annals of the New York Academy of Sciences·M P BlausteinJ M Hamlyn
Apr 21, 1988·The New England Journal of Medicine
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L GaoC J Venglarik
Dec 1, 1989·Clinical Endocrinology·R FraserJ M Connell
Jan 1, 1994·Journal of Clinical Laboratory Analysis·I J Alosachie, P M Lad
Aug 4, 1998·The American Journal of Physiology·Z BebökE J Sorscher
Apr 13, 1999·The American Journal of Physiology·D C Devor, J M Pilewski
Jun 13, 1998·Biochimica Et Biophysica Acta·F C Mooren, R K Kinne
Jan 29, 1988·Biochemical and Biophysical Research Communications·A L Rauch, V M Buckalew

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.