PMID: 9659294Jul 11, 1998Paper

Cholinergic regulation of the rat adrenal zona glomerulosa

The Journal of Endocrinology
A JanossyG P Vinson

Abstract

Using histochemical and immunocytochemical methods, cholinergic nerve fibres were demonstrated in the rat adrenal cortex, primarily in the capsule and zona glomerulosa, and in the medulla. Some terminated among the glomerulosa cells or around blood vessels. Occasional fibres were also seen in the fasciculata, ending in islets of chromaffin tissue without ramifications on cortical cells. To clarify the role of cholinergic innervation, a microvolume perifusion system was used to study steroid production by the rat adrenal capsule-glomerulosa. Acetylcholine (ACh) itself had no reproducible effects; however, since variable amounts of endogenous ACh were present, the actions of antagonists were also studied. The M1 muscarinic receptor antagonist pirenzepine (10 and 100 microM) stimulated aldosterone secretion. This stimulation was abolished by co-incubation with carbachol, the M1 agonist McN A-343 and by atropine. We found that the action of pirenzepine was blocked by nifedipine (Ca2+ channel blocker), suggesting that pirenzepine (through release of endogenous ACh) provides an acute stimulus by enhancing Ca2+ inflow. Hemicholine, a choline uptake blocker, reduced the stimulatory effect of pirenzepine on steroid secretion, confirming...Continue Reading

Citations

Feb 13, 2001·Molecular and Cellular Endocrinology·A JanossyJ Y Li
May 31, 2012·Pharmacology & Therapeutics·Frederick J Mitchelson
Sep 23, 2014·Acta histochemica·Mohamed A Elnasharty, Ahmed Sayed-Ahmed
Jul 6, 2016·Frontiers in Neuroscience·Gavin P Vinson
Jul 2, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Jianli Zheng Caiping Mao
Sep 5, 2006·Human Reproduction·Natsuko TokushigeIan S Fraser

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