PMID: 7932282May 1, 1994Paper

Cholinergic REM induction test: muscarinic supersensitivity underlies polysomnographic findings in both depression and schizophrenia

Journal of Psychiatric Research
D RiemannM Berger


Disinhibition of rapid eye movement (REM) sleep (e.g. shortening of REM latency, heightened REM density) is frequently encountered in patients with a major depressive disorder (MDD). Administration of cholinomimetics prior to or during sleep leads to a more pronounced advance of REM sleep in depressed patients compared to healthy controls and patients with other psychiatric disorders. The present study tested whether the cholinergic REM induction test (CRIT) with 1.5 mg RS 86 (an orally acting muscarinic agonist) differentiates patients with MDD (n = 40) from those with schizophrenia (n = 43) and healthy controls (n = 36). The most pronounced shortening of REM latency after cholinergic stimulation occurred in patients with MDD. However, a significant number of patients with schizophrenia also displayed short REM latencies (REM latency < 25 minutes) under placebo conditions and after cholinergic stimulation. REM density measures more clearly differentiated patients with MDD from those with schizophrenia. It is concluded that a subgroup of patients suffering from schizophrenia displays signs of a muscarinic receptor supersensitivity.


Jul 1, 1979·Psychiatry Research·N SitaramJ C Gillin
May 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·D Riemann, M Berger
Nov 1, 1991·Biological Psychiatry·S F TaylorA S Eiser
Jul 1, 1991·Psychiatry Research·D RiemannM Berger
Aug 1, 1990·Biological Psychiatry·G K ThakerC A Tamminga
Mar 1, 1991·Archives of General Psychiatry·J C GillinD Janowsky
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Nov 27, 1989·Brain Research·J Velazquez-MoctezumaP J Shiromani
Mar 1, 1989·Psychiatry Research·R TandonJ F Greden
Jan 1, 1987·Archives of General Psychiatry·V P ZarconeP A Berger
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Sep 23, 1972·Lancet·D S JanowskyH J Sekerke
Sep 1, 1973·Archives of General Psychiatry·K JusR Lachance
Jun 1, 1967·Comprehensive Psychiatry·G D GulevichV P Zarcone
May 1, 1982·The American Journal of Psychiatry·R W McCarley
Feb 1, 1981·Psychiatry Research·J C GillinW E Bunney
Mar 1, 1994·Psychiatry Research·D RiemannJ B Aldenhoff
Sep 1, 1993·Hearing Research·W Yao, D A Godfrey
Mar 1, 1993·The American Journal of Psychiatry·C N KarsonW S Griffin

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Oct 4, 2006·Archives of General Psychiatry·Maura L Furey, Wayne C Drevets
May 1, 1994·Journal of Psychiatric Research·J C Gillin
Jan 1, 1994·Journal of Psychosomatic Research·D RiemannM Berger
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·J RöschkeJ Fell
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vadim S RotenbergMordechai Mark
Jul 17, 2001·Biological Psychology·D RiemannU Voderholzer
Jun 27, 2002·Psychoneuroendocrinology·Björn AppelbergRanan Rimón
Aug 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura L FureyWayne C Drevets
Apr 2, 2009·Psychiatry and Clinical Neurosciences·Yu-San ChangMing-Chao Chen
Feb 1, 1995·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D RiemannM H Schmidt
Apr 12, 2008·Sleep Medicine·Dieter Riemann
Nov 23, 2006·The Psychiatric Clinics of North America·Kathleen L Benson
Feb 7, 2007·Acta Psychiatrica Scandinavica. Supplementum·R Armitage
Nov 26, 2015·The Psychiatric Clinics of North America·Jayesh KamathAndrew Winokur
Jun 26, 2012·Schizophrenia Research·Tarek K RajjiBenoit H Mulsant
Sep 23, 2011·Biological Psychiatry·Vivek PillaiJeffrey A Ciesla
Oct 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yann S MineurMarina R Picciotto
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Emmanuel StipLuc Jean Boulay
Feb 13, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James ShafferyRoseanne Armitage
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Dec 6, 2006·Molecular Psychiatry·T J RaedlerB Dean
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