PMID: 7932282May 1, 1994Paper

Cholinergic REM induction test: muscarinic supersensitivity underlies polysomnographic findings in both depression and schizophrenia

Journal of Psychiatric Research
D RiemannM Berger

Abstract

Disinhibition of rapid eye movement (REM) sleep (e.g. shortening of REM latency, heightened REM density) is frequently encountered in patients with a major depressive disorder (MDD). Administration of cholinomimetics prior to or during sleep leads to a more pronounced advance of REM sleep in depressed patients compared to healthy controls and patients with other psychiatric disorders. The present study tested whether the cholinergic REM induction test (CRIT) with 1.5 mg RS 86 (an orally acting muscarinic agonist) differentiates patients with MDD (n = 40) from those with schizophrenia (n = 43) and healthy controls (n = 36). The most pronounced shortening of REM latency after cholinergic stimulation occurred in patients with MDD. However, a significant number of patients with schizophrenia also displayed short REM latencies (REM latency < 25 minutes) under placebo conditions and after cholinergic stimulation. REM density measures more clearly differentiated patients with MDD from those with schizophrenia. It is concluded that a subgroup of patients suffering from schizophrenia displays signs of a muscarinic receptor supersensitivity.

References

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Citations

Oct 4, 2006·Archives of General Psychiatry·Maura L Furey, Wayne C Drevets
May 1, 1994·Journal of Psychiatric Research·J C Gillin
Jan 1, 1994·Journal of Psychosomatic Research·D RiemannM Berger
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·J RöschkeJ Fell
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vadim S RotenbergMordechai Mark
Jul 17, 2001·Biological Psychology·D RiemannU Voderholzer
Jun 27, 2002·Psychoneuroendocrinology·Björn AppelbergRanan Rimón
Aug 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura L FureyWayne C Drevets
Apr 2, 2009·Psychiatry and Clinical Neurosciences·Yu-San ChangMing-Chao Chen
Feb 1, 1995·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D RiemannM H Schmidt
Apr 12, 2008·Sleep Medicine·Dieter Riemann
Nov 23, 2006·The Psychiatric Clinics of North America·Kathleen L Benson
Feb 7, 2007·Acta Psychiatrica Scandinavica. Supplementum·R Armitage
Nov 26, 2015·The Psychiatric Clinics of North America·Jayesh KamathAndrew Winokur
Jun 26, 2012·Schizophrenia Research·Tarek K RajjiBenoit H Mulsant
Sep 23, 2011·Biological Psychiatry·Vivek PillaiJeffrey A Ciesla
Oct 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yann S MineurMarina R Picciotto
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Emmanuel StipLuc Jean Boulay
Feb 13, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James ShafferyRoseanne Armitage
Jun 24, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregor HaslerDennis S Charney
Dec 6, 2006·Molecular Psychiatry·T J RaedlerB Dean
Apr 21, 2018·Schizophrenia Research and Treatment·Mohammad Zia Ul Haq KatshuS Haque Nizamie
Apr 27, 2019·Frontiers in Endocrinology·Marcia H RatnerDavid H Farb

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