PMID: 6536292Jul 1, 1984Paper

Cholinergic role in alcohol's effects on evoked potentials in visual cortex of the albino rat

Alcohol
B E Hetzler, T M Smith

Abstract

Photic evoked potentials were recorded from the visual cortex of chronically implanted albino rats. Since photic evoked potential components are representations of neural pathways which are activated during photic stimulation, study of the effects of alcohol on these components may help to trace pathways which are affected by alcohol. In the present study, evoked potentials were recorded at 5, 20, and 40 min following IP injections of saline, ethanol (2.0 g/kg), physostigmine (0.6 mg/kg) or atropine (15.0 mg/kg) on separate days. Ethanol depressed the amplitudes of most evoked potential components in comparison to saline administration. Component P2, however, was increased in amplitude. Physostigmine briefly reduced the amplitude of most components, including P2. In contrast, atropine increased the amplitudes of components P1 and P2, while decreasing components N1, N2 and N3 for varying durations of time. Physostigmine pretreatment augmented the depressant effect of alcohol on the early components P1 and N1, while attenuating alcohol's influence on components P2 and P3. Pretreatment with atropine likewise further reduced the amplitudes of components P1 and N1, and produced a similar effect on component N3. Atropine, either alon...Continue Reading

References

Nov 1, 1977·Journal of Studies on Alcohol·F W ObitzD Creel
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Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·B E HetzlerT Vestal

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Citations

Jan 1, 1987·Physiology & Behavior·R S Dyer, G C Rigdon
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·J A HarveyC W Schindler
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·B E Hetzler, A M Melk
Mar 1, 1988·Neurotoxicology and Teratology·R S DyerL M Mayo
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Maraty Theinpeng
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·B E Hetzler, H L Zeisset
Aug 1, 1993·Alcoholism, Clinical and Experimental Research·K R KrullO A Parsons
Dec 1, 1994·Alcoholism, Clinical and Experimental Research·C KjellströmN G Conradi
Dec 1, 2010·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Elizabeth J Beckman
Jan 25, 2006·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Elizabeth I Martin
Dec 2, 1996·The Journal of Comparative Neurology·A MartínezM Frotscher

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