Cholinergic stimulation with pyridostigmine protects against exercise induced myocardial ischaemia

Heart
R R T CastroA C Nóbrega

Abstract

To determine the acute effects of pyridostigmine bromide, a reversible cholinesterase inhibitor, during exercise in patients with coronary artery disease. Double blind, randomised, placebo controlled, crossover study. Outpatients evaluated in an exercise test laboratory. 15 patients with exercise induced myocardial ischaemia. Maximal cardiopulmonary exercise test on a treadmill according to an individualised ramp protocol on three days. The first day was used for adaptation to the equipment and to determine exercise tolerance and the presence of exercise induced ischaemia. On the other two days, the cardiopulmonary exercise test was performed two hours after oral administration of pyridostigmine (45 mg) or placebo. All patients were taking their usual medication during the experiments. Rate-pressure product and oxygen uptake during exercise. Pyridostigmine inhibited the submaximum chronotropic response (p = 0.001), delaying the onset of myocardial ischaemia, which occurred at a similar rate-pressure product (mean (SE) placebo 20.55 (1.08) mm Hg x beats/min 10(3); pyridostigmine 19.75 (1.28) mm Hg x beats/min 10(3); p = 0.27) but at a higher exercise intensity (oxygen consumption: placebo 18.6 (1.7) ml/kg/min; pyridostigmine 19....Continue Reading

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Citations

Apr 12, 2005·Exercise and Sport Sciences Reviews·Antonio Claudio Lucas da Nobrega
May 25, 2013·Clinical and Experimental Pharmacology & Physiology·Raquel N de La FuenteMaria-Cláudia Irigoyen
Jan 9, 2013·BMC Pharmacology & Toxicology·Rafael Bonfante-CabarcasClaudina Rodríguez-Bonfante
Sep 16, 2014·Mediators of Inflammation·Marília Beatriz de CubaValdo Jose Dias da Silva
Jun 9, 2006·Cardiovascular Drugs and Therapy·Renata Rodrigues Teixeira de CastroAntonio C L Nóbrega
Nov 10, 2009·Life Sciences·Alessandra Teixeira VidalAndrea Grabe-Guimarães
Mar 4, 2009·Journal of Cardiac Failure·Salvador Manoel SerraAntonio Claudio Lucas Da Nóbrega
Sep 26, 2006·Experimental Neurology·Mariana MorrisVera Farah
Dec 13, 2005·International Journal of Cardiology·Renata R T CastroAntonio C L Nóbrega
May 21, 2013·Pharmaceutical Development and Technology·Ana Carolina Moreira SouzaNeila Márcia Silva Barcellos
Jan 20, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L I ZimermanA C L Nóbrega
Aug 28, 2020·Frontiers in Neurology·Laura O'ConnorAnna Rostedt Punga
Jul 18, 2017·Cardiovascular Therapeutics·Renata R T CastroAntonio C L da Nóbrega
Apr 23, 2021·Acta Physiologica·Gisele L CavalcanteJoão Paulo J Sabino
Sep 7, 2021·Physiology·Matthew W KayDavid Mendelowitz

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