PMID: 2092590Jan 1, 1990Paper

Cholinergic system disturbance in the West syndrome

Brain & Development
I RektorC Ménini

Abstract

The effects of drug on the cholinergic system (atropine and physostigmine) were evaluated in acute tests in 12 infant patients with the West syndrome (WS) and in 12 older ones who had suffered from WS at typical ages, displaying various types of epileptic symptoms. In both groups paroxysmal EEG activity was inhibited by physostigmine and enhanced by atropine. In two infants who had frequent clinical seizures, the seizures were temporarily blocked by physostigmine. These effects in WS are different from those reported in some other experimental and clinical epilepsies, where physostigmine has a proepileptic and atropine often an antiepileptic effect, thus indicating that a cholinergic system disturbance may occur in patients with WS.

References

Apr 1, 1983·Epilepsia·R Riikonen
Jan 1, 1981·Folia Psychiatrica Et Neurologica Japonica·Y Yamatogi, S Ohtahara

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Citations

Feb 4, 2005·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·James D Frost, Richard A Hrachovy
Sep 1, 1992·Acta Neurologica Scandinavica·I Rektor, M Svejdová
Jun 1, 1992·The Japanese Journal of Psychiatry and Neurology·M ShimohiraY Iwakawa
Apr 11, 2018·Scientific Reports·Dumitru A IacobaşLibor Velíšek
Aug 4, 1998·The American Journal of Physiology·T KushikataJ M Krueger
May 8, 1999·The American Journal of Physiology·T KushikataJ M Krueger

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