Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates

Toxicology and Applied Pharmacology
Theodore A Slotkin

Abstract

Acetylcholine and other neurotransmitters play unique trophic roles in brain development. Accordingly, drugs and environmental toxicants that promote or interfere with neurotransmitter function evoke neurodevelopmental abnormalities by disrupting the timing or intensity of neurotrophic actions. The current review discusses three exposure scenarios involving acetylcholine systems: nicotine from maternal smoking during pregnancy, exposure to environmental tobacco smoke (ETS), and exposure to the organophosphate insecticide, chlorpyrifos (CPF). All three have long-term, adverse effects on specific processes involved in brain cell replication and differentiation, synaptic development and function, and ultimately behavioral performance. Many of these effects can be traced to the sequence of cellular events surrounding the trophic role of acetylcholine acting on its specific cellular receptors and associated signaling cascades. However, for chlorpyrifos, additional noncholinergic mechanisms appear to be critical in establishing the period of developmental vulnerability, the sites and type of neural damage, and the eventual outcome. New findings indicate that developmental neurotoxicity extends to late phases of brain maturation inclu...Continue Reading

References

Oct 1, 1978·British Journal of Obstetrics and Gynaecology·R L Naeye
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Aug 21, 1992·Brain Research. Developmental Brain Research·B NaeffW Lichtensteiger
Dec 1, 1992·Journal of Developmental and Behavioral Pediatrics : JDBP·R L Naeye
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Feb 22, 1991·Brain Research. Developmental Brain Research·B J McFarlandT A Slotkin
Jan 1, 1991·Neurotoxicology and Teratology·J MakinB Watkinson
Jan 1, 1990·Neuropsychologia·P R Huttenlocher
Jun 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·K A SadykovaG A Buznikov
Jan 1, 1988·Progress in Brain Research·W LichtensteigerH R Widmer
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Yanai, C G Pick
Dec 13, 1988·Brain Research·N J Cairns, S Wonnacott
Apr 27, 1987·Life Sciences·L C MurrinN J Haley
Jan 1, 1986·Biology of the Neonate·T J de GrauwW J Scott
Jan 1, 1986·Biology of the Neonate·H A NasratF A Mahmood
Dec 8, 1973·British Medical Journal·N R Butler, H Goldstein
Jan 1, 1983·Experimental Brain Research·S A Bayer
Apr 1, 1995·Pediatric Clinics of North America·G L Bell, K Lau
Sep 1, 1995·Toxicology and Applied Pharmacology·K D WhitneyT A Slotkin
Dec 16, 1994·Brain Research. Developmental Brain Research·S N PenningtonL W Means

❮ Previous
Next ❯

Citations

Apr 2, 2009·Environmental Health Perspectives·Theodore A SlotkinKarl G Linden
Jan 24, 2009·Environmental Health Perspectives·Sabrina TaitGemma Calamandrei
Mar 20, 2014·Neurotoxicology and Teratology·Theodore A SlotkinFrederic J Seidler
Apr 14, 2006·Psychopharmacology·Andres NeuhausJürgen Gallinat
Sep 10, 2014·Current Problems in Pediatric and Adolescent Health Care·Amy E KalkbrennerAnnie C Penlesky
Oct 26, 2014·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lauren M Dutra, Stanton A Glantz
Oct 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Stanley ZammitGlynn Harrison
Oct 6, 2005·Environmental Health Perspectives·Theodore A SlotkinFrederic J Seidler
Oct 20, 2005·Occupational and Environmental Medicine·W J LeeM H Ward
Sep 7, 2007·Environmental Health Perspectives·Theodore A SlotkinFrederic J Seidler
Mar 13, 2008·Environmental Health Perspectives·Theodore A SlotkinFrederic J Seidler
Jun 19, 2008·Environmental Health Perspectives·Theodore A SlotkinFrederic J Seidler
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sameera M KassamEvelyn K Lambe
Oct 24, 2008·Environmental Health : a Global Access Science Source·Marina Bjørling-PoulsenPhilippe Grandjean
Apr 18, 2009·Developmental Neuroscience·Aliya L Frederick, Gregg D Stanwood
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claudio CoddouJaime Eugenín
Nov 20, 2009·Environmental Science & Technology·Devon Payne-SturgesTracey J Woodruff
Jan 9, 2010·Environmental Health Perspectives·Charles M ThompsonKathleen M George
Feb 27, 2010·Environmental Health Perspectives·Raul HarariPhilippe Grandjean
Feb 25, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dongren YangPamela J Lein
Apr 5, 2011·Indian Journal of Occupational and Environmental Medicine·Abdul Rashid BhatA R Kirmani
Apr 22, 2011·Environmental Health Perspectives·Virginia RauhRobin Whyatt
Aug 23, 2011·Lipids in Health and Disease·Afaf K El-AnsaryAmina R El-Gezeery
Feb 7, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Danielle S CounotteSabine Spijker
Jun 20, 2012·The Journal of Genetic Psychology·Judith S BrookDavid W Brook
Sep 8, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Gustavo Roberto ThoméCinthia Melazzo Mazzanti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis