Cholinesterase activities and biochemical determinations in patients with prostate cancer: influence of Gleason score, treatment and bone metastasis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Vanessa BattistiVera M Morsch

Abstract

Prostate cancer (PCa) is the sixth most common type of cancer worldwide. Cholinesterase is well known as having non-cholinergic functions such as cellular proliferation and differentiation, suggesting a possible influence of cholinesterase in tumorogenesis. Thus, the aim of this study was to investigate the whole blood acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) activities and some biochemical parameters in PCa patients. This study was performed in 66 PCa patients and 40 control subjects. AChE and BChE activities were determined in PCa patients and the influence of the Gleason score; bone metastasis and treatment in the enzyme activities were also verified. Furthermore, we also analyzed possible biochemical alterations in these patients. AChE and BChE activities decreased in PCa patients in relation to the control group and various biochemical changes were observed in these patients. Moreover, Gleason score, metastasis and treatment influenced cholinesterase activities and biochemical determinations. Our results suggest that cholinesterases activities and biochemical parameters are altered in PCa. These facts support the idea that the drop in the cholinesterase activity and the consequent increased amoun...Continue Reading

References

Mar 1, 1992·Human Pathology·D F Gleason
Sep 1, 1990·The Journal of Clinical Investigation·H ZakutH Soreq
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P G Layer, O Sporns
Jan 1, 1995·Progress in Histochemistry and Cytochemistry·P G Layer, E Willbold
Jun 1, 1993·Anti-cancer Drugs·G Alivizatos, G O Oosterhof
Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·F WorekP Eyer
Apr 6, 2000·International Journal of Epidemiology·S LiuC H Hennekens
Sep 21, 2000·Pathophysiology : the Official Journal of the International Society for Pathophysiology·K Kannan, S K Jain
Feb 24, 2001·Human & Experimental Toxicology·A RodgmanT A Perfetti
Oct 9, 2001·Epidemiologic Reviews·L K Dennis, R B Hayes
Oct 9, 2001·Epidemiologic Reviews·M E Parent, J Siemiatycki
May 10, 2002·Breast Cancer Research and Treatment·Francisco Ruiz-EspejoCecilio J Vidal
Jul 11, 2002·Cell Death and Differentiation·X J ZhangY F Shi
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oren SmaletzMichael W Kattan
Jan 29, 2003·JPEN. Journal of Parenteral and Enteral Nutrition·Christopher G LisCarolyn A Lammersfeld
Feb 4, 2003·Nature Reviews. Neuroscience·Sultan DarveshChangiz Geula
Aug 2, 2003·Breast Cancer Research and Treatment·Francisco Ruiz-EspejoCecilio J Vidal
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jul 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Prabhat K Tandon, Ali A Rizvi
Nov 1, 2005·Chemico-biological Interactions·Cecilio J Vidal
Jan 24, 2006·Chemico-biological Interactions·María Fernanda MontenegroCecilio J Vidal
May 9, 2006·Current Opinion in Urology·Timothy J Daskivich, William K Oh
Mar 14, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sang-Yeon Suh, Hong-Yup Ahn
Apr 6, 2007·Cancer·Takeshi SuzukiKazuo Tajima
Nov 23, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maísa de Carvalho CorrêaMaria Rosa Schetinger
Feb 12, 2008·Seminars in Cancer Biology·Laura PaleariPatrizia Russo
Jun 12, 2008·International Journal of Cancer. Journal International Du Cancer·Jiyoung AhnDemetrius Albanes
Feb 3, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vanessa BattistiVera M Morsch
Mar 3, 2010·Cancer Genetics and Cytogenetics·Caroline C BernardiRicardo L R Souza
Apr 2, 2010·Chemico-biological Interactions·Susana Nieto-CerónJuan Cabezas-Herrera
May 22, 2010·Hematology/oncology Clinics of North America·Melissa L Givens, Joy Crandall
Apr 14, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mieke Van HemelrijckLars Holmberg

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Citations

Dec 31, 2016·International Journal of Molecular Sciences·Dong Gui HuRobyn Meech
Apr 5, 2017·Journal of Pediatric Hematology/oncology·Don W CoulterJanina Baranowska-Kortylewicz
Jul 15, 2021·Pathology Oncology Research : POR·Yanzhi BiYang Ling

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