PMID: 1094493Jan 1, 1975

Cholinesterase in embryonic development

Progress in Histochemistry and Cytochemistry
U Drews

Abstract

I. Cholinesterase (ChE) activity was studied histochemically during early development of the sea urchin, the amphibian, the chick and the rat embryo. After formalin fixation and embedding in water-soluble carbowax, the enzyme reaction was carried out in serial section. 2. Independent from innervation ChE appears in every embryonic blastema in a very early stage of development. It disappears from the embryonic cells after they have assembled into definite organ structures. Thus, ChE plays a role in embryonic development which is different from its known function in the adult. Therefore, ChE activity present in differentiating cells during a limited phase of development, is termed "embryonic cholinesterase". 3. Embryonic ChE was invariably found in cells engaged in morphogenetic movements. This observation has led us to suppose that the enzyme in involved in the regulation of cellular movements during development. 4. In particular, embryonic ChE is described in the following locations: a) During sea urchin gastrulation ChE is present in the primary mesenchymal cells emigrating from the blastula wall and in the archenteron cells which are known to bring about the invagination movement by contraction of their pseudopods. b) In the ...Continue Reading

References

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Citations

May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E NeumannA Katchalsky
Aug 1, 1967·Biological Reviews of the Cambridge Philosophical Society·T GUSTAFSON, L Wolpert
Sep 1, 1972·The American Journal of Anatomy·W J Swartz, L V Domm
Jan 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·H G Coon
Jan 15, 1971·Science·N K WessellsK Yamada
Oct 1, 1953·The Anatomical Record·D G McKAYS DANZIGER
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS
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Oct 1, 1949·Journal of Cellular Physiology·K B AUGUSTINSSON, T GUSTAFSON
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Embryo
Amphibians
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Formalin
Entire Embryo
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