Cholinesterase inhibition and depression of the photic after discharge of flash evoked potentials following acute or repeated exposures to a mixture of carbaryl and propoxur

Neurotoxicology
Jean-Claude MwanzaDavid W Herr

Abstract

Previously, we reported that acute treatment with propoxur or carbaryl decreased the duration of the photic after discharge (PhAD) of flash evoked potentials (FEPs). In the current studies, we compared the effects of acute or repeated exposure to a mixture of carbaryl and propoxur (1:1.45 ratio; propoxur:carbaryl) on the duration of the PhAD and brain ChE activity in Long Evans rats. Animals were exposed (po) either to a single dose (0, 3, 10, 45 or 75 mg/kg), or 14 daily dosages (0, 3, 10, 30, 45 mg/kg), of the mixture. Acute and repeated treatment with 3mg/kg (or greater) of the mixture produced dose-related inhibition of brain ChE activity. Compared to controls, the PhAD duration decreased after acute administration of 75 mg/kg or repeated treatment with 30 mg/kg of the mixture. The linear relationship between the percent of control brain ChE activity and the PhAD duration was similar for both exposure paradigms. Dose-response models for the acute and repeated exposure data did not differ for brain ChE activity or the duration of the PhAD. Repeated treatment with the mixture resulted in slightly less (13-22%) erythrocyte ChE inhibition than acute exposure. Both acute and repeated treatment resulted in dose-additive results f...Continue Reading

References

Nov 1, 1975·Electroencephalography and Clinical Neurophysiology·E D Bigler
Mar 1, 1975·Analytical Biochemistry·C D Johnson, R L Russell
Jun 1, 1978·Pharmacology, Biochemistry, and Behavior·E D BiglerD E Fleming
Sep 1, 1991·Electroencephalography and Clinical Neurophysiology·R JanssenR S Dyer
Jul 1, 1985·Electroencephalography and Clinical Neurophysiology·M A KrautH G Vaughan
Aug 1, 1988·Electroencephalography and Clinical Neurophysiology·B E HetzlerR S Dyer
Sep 1, 1988·Neurotoxicology and Teratology·J L Mattsson, R R Albee
Aug 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·V C MoserR C MacPhail
Aug 1, 1973·Electroencephalography and Clinical Neurophysiology·T Miyoshi, I Goto
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D E FlemingD J Creel
Jun 1, 1972·Physiology & Behavior·D E FlemingD E Shearer
Jan 1, 1993·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·W K BoyesR S Dyer
Jan 27, 1998·Regulatory Toxicology and Pharmacology : RTP·H R PohlC H Chou
Sep 26, 2000·Electroencephalography and Clinical Neurophysiology·G J RuttenH Franssen
Apr 16, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chris GenningsRichard A Carchman
Aug 6, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·C GenningsE W Carney
Apr 14, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Virginia C MoserChris Gennings
Apr 25, 2007·Journal of Toxicology and Environmental Health. Part a·Cina M Mack, Christopher J Gordon
May 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katherine L McDanielVirginia C Moser
Jun 28, 2008·Contemporary Clinical Trials·Robert H LylesCarlton R Cooper
Nov 26, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Virginia C MoserAnna B Lowit
Nov 1, 2004·Environmental Toxicology and Pharmacology·Chris GenningsJane Ellen Simmons

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Citations

Nov 14, 2012·Toxicology·Richard C HertzbergJane Ellen Simmons
Sep 10, 2014·Neurotoxicology·Mariel MullerOscar Scremin
Jun 18, 2016·Chemico-biological Interactions·V RizzatiL Gamet-Payrastre

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